OBJECTIVE: To investigate mortality of children diagnosed with insulin dependent diabetes mellitus (IDDM) and to identify common factors before death. DESIGN: Follow up of a population based cohort of children diagnosed with IDDM to ascertain deaths. SETTING: Children were diagnosed in Yorkshire but followed up throughout the United Kingdom. SUBJECTS: From the Yorkshire Children's Diabetes Register details of 1854 children aged 0-16 years (1978-93) were submitted to the NHS Central Register. MAIN OUTCOME MEASURE: Notification and causes of death. RESULTS: 98.3% of cases were traced and 26 deaths identified. Follow up ranged from 1-18 years (median 9.3 years), providing 17,350 person-years of IDDM. Fifteen deaths (58%) were attributed to diabetes or its complications; 11 (42%) were unrelated and included one suicide. For mortality from all causes, the standardised mortality ratio (SMR) of 247 (95% confidence interval (CI) 163 to 362) was significantly increased for those under 34 years. The largest number of deaths (n = 10) occurred in the 15-19 year age range, with an SMR of 442 (95% CI 209 to 802). Case note examination showed a clear tendency towards poor diabetic control, and worries over control were expressed before death by health care professionals. CONCLUSIONS: Despite advances in treatment, IDDM still carries an increased mortality for young people, particularly in the "transition" age range.
OBJECTIVE: To investigate mortality of children diagnosed with insulin dependent diabetes mellitus (IDDM) and to identify common factors before death. DESIGN: Follow up of a population based cohort of children diagnosed with IDDM to ascertain deaths. SETTING:Children were diagnosed in Yorkshire but followed up throughout the United Kingdom. SUBJECTS: From the Yorkshire Children's Diabetes Register details of 1854 children aged 0-16 years (1978-93) were submitted to the NHS Central Register. MAIN OUTCOME MEASURE: Notification and causes of death. RESULTS: 98.3% of cases were traced and 26 deaths identified. Follow up ranged from 1-18 years (median 9.3 years), providing 17,350 person-years of IDDM. Fifteen deaths (58%) were attributed to diabetes or its complications; 11 (42%) were unrelated and included one suicide. For mortality from all causes, the standardised mortality ratio (SMR) of 247 (95% confidence interval (CI) 163 to 362) was significantly increased for those under 34 years. The largest number of deaths (n = 10) occurred in the 15-19 year age range, with an SMR of 442 (95% CI 209 to 802). Case note examination showed a clear tendency towards poor diabetic control, and worries over control were expressed before death by health care professionals. CONCLUSIONS: Despite advances in treatment, IDDM still carries an increased mortality for young people, particularly in the "transition" age range.
Authors: J S Dorman; R E Laporte; L H Kuller; K J Cruickshanks; T J Orchard; D K Wagener; D J Becker; D E Cavender; A L Drash Journal: Diabetes Date: 1984-03 Impact factor: 9.461
Authors: S S Soedamah-Muthu; J H Fuller; H E Mulnier; V S Raleigh; R A Lawrenson; H M Colhoun Journal: Diabetologia Date: 2006-01-24 Impact factor: 10.122
Authors: I Waernbaum; G Blohmé; J Ostman; G Sundkvist; J W Eriksson; H J Arnqvist; J Bolinder; L Nyström Journal: Diabetologia Date: 2006-01-31 Impact factor: 10.122
Authors: Ryan M Hill; Katherine A S Gallagher; Sahar S Eshtehardi; Serife Uysal; Marisa E Hilliard Journal: Curr Diab Rep Date: 2021-12-13 Impact factor: 4.810
Authors: Montse Vergara-Duarte; Carme Borrell; Glòria Pérez; Juan Carlos Martín-Sánchez; Ramon Clèries; Maria Buxó; Èrica Martínez-Solanas; Yutaka Yasui; Carles Muntaner; Joan Benach Journal: Biomed Res Int Date: 2018-09-02 Impact factor: 3.411
Authors: Carlos A Andrade-Castellanos; Luis Enrique Colunga-Lozano; Netzahualpilli Delgado-Figueroa; Daniel A Gonzalez-Padilla Journal: Cochrane Database Syst Rev Date: 2016-01-21