Literature DB >> 9658140

The probability of in vivo reactivation of herpes simplex virus type 1 increases with the number of latently infected neurons in the ganglia.

N M Sawtell1.   

Abstract

The purpose of this study was to define the relationship between herpes simplex virus (HSV) latency and in vivo ganglionic reactivation. Groups of mice with numbers of latently infected neurons ranging from 1.9 to 24% were generated by varying the input titer of wild-type HSV type 1 strain 17syn+. Reactivation of the virus in mice from each group was induced by hyperthermic stress. The number of animals that exhibited virus reactivation was positively correlated with the number of latently infected neurons in the ganglia over the entire range examined (r = 0.9852, P < 0. 0001 [Pearson correlation]).

Entities:  

Mesh：

Substances：

Year:  1998        PMID： 9658140      PMCID： PMC109900     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  32 in total

1.  The latent herpes simplex virus type 1 genome copy number in individual neurons is virus strain specific and correlates with reactivation.

Authors:  N M Sawtell; D K Poon; C S Tansky; R L Thompson
Journal:  J Virol       Date:  1998-07       Impact factor: 5.103

2.  Quantitative polymerase chain reaction analysis of herpes simplex virus DNA in ganglia of mice infected with replication-incompetent mutants.

Authors:  J P Katz; E T Bodin; D M Coen
Journal:  J Virol       Date:  1990-09       Impact factor: 5.103

3.  Immediate-early regulatory gene mutants define different stages in the establishment and reactivation of herpes simplex virus latency.

Authors:  D A Leib; D M Coen; C L Bogard; K A Hicks; D R Yager; D M Knipe; K L Tyler; P A Schaffer
Journal:  J Virol       Date:  1989-02       Impact factor: 5.103

4.  A herpes simplex virus type 1 mutant containing a nontransinducing Vmw65 protein establishes latent infection in vivo in the absence of viral replication and reactivates efficiently from explanted trigeminal ganglia.

Authors:  I Steiner; J G Spivack; S L Deshmane; C I Ace; C M Preston; N W Fraser
Journal:  J Virol       Date:  1990-04       Impact factor: 5.103

5.  A deletion mutant of the latency-associated transcript of herpes simplex virus type 1 reactivates from the latent state with reduced frequency.

Authors:  D A Leib; C L Bogard; M Kosz-Vnenchak; K A Hicks; D M Coen; D M Knipe; P A Schaffer
Journal:  J Virol       Date:  1989-07       Impact factor: 5.103

6.  The natural history of recurrent herpes simplex labialis: implications for antiviral therapy.

Authors:  S L Spruance; J C Overall; E R Kern; G G Krueger; V Pliam; W Miller
Journal:  N Engl J Med       Date:  1977-07-14       Impact factor: 91.245

7.  Relation of target encounter and neuronal death to nerve growth factor responsiveness in the developing mouse trigeminal ganglion.

Authors:  A Davies; A Lumsden
Journal:  J Comp Neurol       Date:  1984-02-10       Impact factor: 3.215

8.  Reactivation in vivo and in vitro of herpes simplex virus from mouse dorsal root ganglia which contain different levels of latency-associated transcripts.

Authors:  M S Ecob-Prince; F J Rixon; C M Preston; K Hassan; P G Kennedy
Journal:  J Gen Virol       Date:  1993-06       Impact factor: 3.891

9.  Herpes simplex virus type 1 latency-associated transcription unit promotes anatomical site-dependent establishment and reactivation from latency.

Authors:  N M Sawtell; R L Thompson
Journal:  J Virol       Date:  1992-04       Impact factor: 5.103

10.  Rapid in vivo reactivation of herpes simplex virus in latently infected murine ganglionic neurons after transient hyperthermia.

Authors:  N M Sawtell; R L Thompson
Journal:  J Virol       Date:  1992-04       Impact factor: 5.103
View more
  71 in total

1.  Enhancer and long-term expression functions of herpes simplex virus type 1 latency-associated promoter are both located in the same region.

Authors:  H Berthomme; J Thomas; P Texier; A Epstein; L T Feldman
Journal:  J Virol       Date:  2001-05       Impact factor: 5.103

2.  Prophylactic and therapeutic effects of human immunoglobulin on the pathobiology of HSV-1 infection, latency, and reactivation in mice.

Authors:  Sarat K Dalai; Lesley Pesnicak; Georgina F Miller; Stephen E Straus
Journal:  J Neurovirol       Date:  2002-02       Impact factor: 2.643

Review 3.  HSV-1-based vectors for gene therapy of neurological diseases and brain tumors: part I. HSV-1 structure, replication and pathogenesis.

Authors:  A Jacobs; X O Breakefield; C Fraefel
Journal:  Neoplasia       Date:  1999-11       Impact factor: 5.715

4.  VP16 serine 375 is a critical determinant of herpes simplex virus exit from latency in vivo.

Authors:  Nancy M Sawtell; Steven J Triezenberg; Richard L Thompson
Journal:  J Neurovirol       Date:  2011-12-06       Impact factor: 2.643

5.  The relationship of herpes simplex virus latency associated transcript expression to genome copy number: a quantitative study using laser capture microdissection.

Authors:  Xiao-Ping Chen; Marina Mata; Mary Kelley; Joseph C Glorioso; David J Fink
Journal:  J Neurovirol       Date:  2002-06       Impact factor: 2.643

6.  Quantitative analysis of herpes simplex virus reactivation in vivo demonstrates that reactivation in the nervous system is not inhibited at early times postinoculation.

Authors:  N M Sawtell
Journal:  J Virol       Date:  2003-04       Impact factor: 5.103

7.  Failure of thymidine kinase-negative herpes simplex virus to reactivate from latency following efficient establishment.

Authors:  Shih-Heng Chen; Angela Pearson; Donald M Coen; Shun-Hua Chen
Journal:  J Virol       Date:  2004-01       Impact factor: 5.103

8.  Analysis of herpes simplex virus ICP0 promoter function in sensory neurons during acute infection, establishment of latency, and reactivation in vivo.

Authors:  R L Thompson; May T Shieh; N M Sawtell
Journal:  J Virol       Date:  2003-11       Impact factor: 5.103

9.  Wide variations in herpes simplex virus type 1 inoculum dose and latency-associated transcript expression phenotype do not alter the establishment of latency in the rabbit eye model.

Authors:  J E O'Neil; J M Loutsch; J S Aguilar; J M Hill; E K Wagner; D C Bloom
Journal:  J Virol       Date:  2004-05       Impact factor: 5.103

10.  Comparison of herpes simplex virus reactivation in ganglia in vivo and in explants demonstrates quantitative and qualitative differences.

Authors:  N M Sawtell; R L Thompson
Journal:  J Virol       Date:  2004-07       Impact factor: 5.103
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.