PURPOSE: The authors describe the clinicopathologic features of an anterior variant of diffuse retinoblastoma. METHODS: The clinical history of a child with an anterior chamber infiltrate and cells in the anterior vitreous was reviewed. An anterior chamber aspirate was processed by a Millipore filter technique. The eye was enucleated and routinely processed for light and transmission electron microscopic examination. RESULTS: An 8-year-old girl was treated for anterior uveitis in her right eye that failed to resolve. Examination of an anterior chamber aspirate showed cells suggestive of retinoblastoma. The eye was enucleated, and the enucleation specimen showed retinoblastoma confined to the iris, ciliary body, and anterior vitreous with one microscopic focus of tumor in the peripheral retina. CONCLUSION: This variant of diffuse retinoblastoma involved only anterior ocular structures with minimal involvement of the retina.
PURPOSE: The authors describe the clinicopathologic features of an anterior variant of diffuse retinoblastoma. METHODS: The clinical history of a child with an anterior chamber infiltrate and cells in the anterior vitreous was reviewed. An anterior chamber aspirate was processed by a Millipore filter technique. The eye was enucleated and routinely processed for light and transmission electron microscopic examination. RESULTS: An 8-year-old girl was treated for anterior uveitis in her right eye that failed to resolve. Examination of an anterior chamber aspirate showed cells suggestive of retinoblastoma. The eye was enucleated, and the enucleation specimen showed retinoblastoma confined to the iris, ciliary body, and anterior vitreous with one microscopic focus of tumor in the peripheral retina. CONCLUSION: This variant of diffuse retinoblastoma involved only anterior ocular structures with minimal involvement of the retina.