Literature DB >> 96524

Excitation-contraction coupling in skeletal muscle: blockade by high extracellular concentrations of calcium buffers.

N Barrett, E F Barrett.   

Abstract

High concentrations (80 to 90 millimolar) of the calcium buffers EGTA and citrate (less than 10(-7) molar free calcium ion) reversibly block excitation-contraction coupling in intact frog skeletal fibers, but do not block caffeine-induced contractures. Solutions containing the same free calcium concentration but lower concentrations of calcium buffer (1 millimolar) do not block excitation-contraction coupling. These results suggest that excitation-contraction coupling requires the presence of calcium in a "protected" extracellular compartment, probably the transverse tubular network, and that calcium is actively transported into this compartment from the muscle cell cytoplasm.

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Year:  1978        PMID： 96524     DOI： 10.1126/science.96524

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  18 in total

1.  Feet, bridges, and pillars in triad junctions of mammalian skeletal muscle: their possible relationship to calcium buffers in terminal cisternae and T-tubules and to excitation-contraction coupling.

Authors:  A F Dulhunty
Journal:  J Membr Biol       Date:  1989-07       Impact factor: 1.843

2.  Voltage sensors of the frog skeletal muscle membrane require calcium to function in excitation-contraction coupling.

Authors:  G Brum; R Fitts; G Pizarro; E Ríos
Journal:  J Physiol       Date:  1988-04       Impact factor: 5.182

3.  Mechanism of calcium release from skeletal sarcoplasmic reticulum.

Authors:  H Miyamoto; E Racker
Journal:  J Membr Biol       Date:  1982       Impact factor: 1.843

Review 4.  Monovalent ion and calcium ion fluxes in sarcoplasmic reticulum.

Authors:  G Meissner
Journal:  Mol Cell Biochem       Date:  1983       Impact factor: 3.396

5.  Purification of the putative calcium channel from skeletal muscle with the aid of [3H]-nimodipine binding.

Authors:  H Glossmann; D R Ferry; C B Boschek
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1983-06       Impact factor: 3.000

6.  Comparison of the action of La3+ and Ca2+ on contraction threshold and other membrane parameters of frog skeletal muscle.

Authors:  M Dörrscheidt-Käfer
Journal:  J Membr Biol       Date:  1981       Impact factor: 1.843

7.  Mechanical activation in slow and twitch skeletal muscle fibres of the frog.

Authors:  W F Gilly; C S Hui
Journal:  J Physiol       Date:  1980-04       Impact factor: 5.182

8.  The effects of calcium deprivation upon mechanical and electrophysiological parameters in skeletal muscle fibres of the frog.

Authors:  H C Lüttgau; W Spiecker
Journal:  J Physiol       Date:  1979-11       Impact factor: 5.182

9.  The action of serotonin on excitatory nerve terminals in lobster nerve-muscle preparations.

Authors:  S Glusman; E A Kravitz
Journal:  J Physiol       Date:  1982-04       Impact factor: 5.182

10.  Nickel substitution for calcium and the time course of potassium contractures of single muscle fibres.

Authors:  C Caputo
Journal:  J Muscle Res Cell Motil       Date:  1981-06       Impact factor: 2.698
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