Literature DB >> 9649671

Surgery and cyclosporine A in the treatment of erosive lichen planus of the feet.

P Patrone1, G Stinco, E La Pia, A Frattasio, V De Francesco.   

Abstract

Erosive lichen planus is known to be relatively unresponsive to medical treatment. Surgery could be an alternative treatment for this disease. We report the case of a 68-year-old man with a 10-year history of painful, disabling, ulcerative lesions on the soles of both feet. All previous topical and oral treatments had failed and his condition was gradually worsening. Cyclosporine A was administered twice. The first time, systemic cyclosporine A gave a marked but only temporary improvement. The second time, treatment with cyclosporine A was begun 10 days before the ulcer on his left sole was covered with a Thiersch split-skin graft. The grafting was successful, so cyclosporine A was gradually reduced to smaller maintenance doses and 10 months later it was completely withdrawn. The patient refused to undergo surgery on his right foot thus providing the opportunity to compare the results. At the present time, eighteen months following grafting and ten months after total withdrawal of cyclosporine A, the condition of the left sole is stable and free from pain while the ungrafted ulcer on his right sole is still painful and has increased in size.

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Year:  1998        PMID: 9649671

Source DB:  PubMed          Journal:  Eur J Dermatol        ISSN: 1167-1122            Impact factor:   3.328


  6 in total

1.  [Ulcerated plantar lichen planus. Successful treatment with cyclosporine].

Authors:  R Renner; R Treudler; C Gebhardt; J C Simon
Journal:  Hautarzt       Date:  2009-08       Impact factor: 0.751

2.  Cyclosporin A reduces matrix metalloproteinases and collagen expression in dermal fibroblasts from regenerative FOXN1 deficient (nude) mice.

Authors:  Barbara Gawronska-Kozak; Heather Kirk-Ballard
Journal:  Fibrogenesis Tissue Repair       Date:  2013-04-02

3.  Erosive lichen planus: a therapeutic challenge.

Authors:  Williams Romero; Laura Giesen; Lucas Navajas-Galimany; Sergio Gonzalez
Journal:  An Bras Dermatol       Date:  2016 Jan-Feb       Impact factor: 1.896

Review 4.  Treatment modalities of palmoplantar lichen planus: a brief review.

Authors:  Amir Feily; Reza Yaghoobi; Mohammad Ali Nilforoushzadeh
Journal:  Postepy Dermatol Alergol       Date:  2016-12-02       Impact factor: 1.837

5.  Autologous micrografts and methotrexate in plantar erosive lichen planus: healing and pain control. A case report.

Authors:  G Miotti; N Zingaretti; G F Guarneri; V Manfrè; E Errichetti; G Stinco; P C Parodi
Journal:  Case Reports Plast Surg Hand Surg       Date:  2020-12-28

6.  Erosive lichen planus of the soles: Effective response to prednisone.

Authors:  Samia Goucha; Aida Khaled; Zaineb Bennani; Soumeya Rammeh; Faten Zéglaoui; Rachida Zermani; Bécima Fazaa
Journal:  Dermatol Ther (Heidelb)       Date:  2011-08-22
  6 in total

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