BACKGROUND: Perinuclear antineutrophil antibodies (P-ANCA) are found in ulcerative colitis, and autoantibodies against exocrine pancreas (PAB) in Crohn's disease. Their potential role as genetic or pathophysiologic factors is unclear. METHODS: In 61 patients with ulcerative colitis, 76 patients with Crohn's disease, 101 first-degree relatives of patients with ulcerative colitis, 105 first-degree relatives of Crohn's disease patients, and 56 healthy unrelated controls autoantibodies were detected by indirect immunofluorescence. RESULTS: Forty-six per cent of patients with ulcerative colitis (28 of 61) and 38% of patients with Crohn's disease (29 of 76) were P-ANCA- and PAB-positive, respectively. In relatives of patients with ulcerative colitis P-ANCA were found in 3% (3 of 101), and in relatives of Crohn's disease patients PAB were detected in 4% (4 of 105), which is not significantly different from the occurrence in the healthy controls. CONCLUSIONS: The frequency of P-ANCA and PAB does not suggest a role as genetic markers for inflammatory bowel disease.
BACKGROUND: Perinuclear antineutrophil antibodies (P-ANCA) are found in ulcerative colitis, and autoantibodies against exocrine pancreas (PAB) in Crohn's disease. Their potential role as genetic or pathophysiologic factors is unclear. METHODS: In 61 patients with ulcerative colitis, 76 patients with Crohn's disease, 101 first-degree relatives of patients with ulcerative colitis, 105 first-degree relatives of Crohn's diseasepatients, and 56 healthy unrelated controls autoantibodies were detected by indirect immunofluorescence. RESULTS: Forty-six per cent of patients with ulcerative colitis (28 of 61) and 38% of patients with Crohn's disease (29 of 76) were P-ANCA- and PAB-positive, respectively. In relatives of patients with ulcerative colitis P-ANCA were found in 3% (3 of 101), and in relatives of Crohn's diseasepatientsPAB were detected in 4% (4 of 105), which is not significantly different from the occurrence in the healthy controls. CONCLUSIONS: The frequency of P-ANCA and PAB does not suggest a role as genetic markers for inflammatory bowel disease.
Authors: Ioannis E Koutroubakis; Dimitrios Drygiannakis; Konstantinos Karmiris; Ioannis Drygiannakis; Sokratis Makreas; Elias A Kouroumalis Journal: Dig Dis Sci Date: 2005-12 Impact factor: 3.199
Authors: Lani Prideaux; Michael A Kamm; Peter De Cruz; Daniel R van Langenberg; Siew C Ng; Iris Dotan Journal: World J Gastroenterol Date: 2013-10-07 Impact factor: 5.742
Authors: Frank H Klebl; Frauke Bataille; Ferdinand Hofstädter; Hans Herfarth; Jürgen Schölmerich; Gerhard Rogler Journal: Int J Colorectal Dis Date: 2004-01-27 Impact factor: 2.571