Literature DB >> 9647201

The expression in vivo of a second isoform of pT alpha: implications for the mechanism of pT alpha action.

D F Barber1, L Passoni, L Wen, L Geng, A C Hayday.   

Abstract

A second isoform of pT alpha, "pT alpha(b)," is derived from the pT alpha locus by tissue-specific, alternative splicing. pT alpha(b) is coexpressed in the thymus with the previously characterized form of pT alpha (which we term pT alpha(a)) and is also expressed in peripheral cells without pT alpha(a). While pT alpha(a) acts to retain most TCR beta-chains intracellularly, pT alpha(b) permits higher levels of cell surface TCR beta expression and facilitates signaling from a CD3-TCR beta complex.

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Year:  1998        PMID： 9647201

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  12 in total

1.  How alpha beta T cells deal with induced TCR alpha ablation.

Authors:  B Polic; D Kunkel; A Scheffold; K Rajewsky
Journal:  Proc Natl Acad Sci U S A       Date:  2001-07-10       Impact factor: 11.205

Review 2.  Oligoclonal Th2-biased betabeta T cells induce murine inflammatory bowel disease.

Authors:  I Takahashi; H Lijima; D Kishi; H Kiyono
Journal:  Immunol Res       Date:  1999       Impact factor: 2.829

3.  Induction of differentiation of pre-NKT cells to mature Valpha14 NKT cells by granulocyte/macrophage colony-stimulating factor.

Authors:  H Sato; T Nakayama; Y Tanaka; M Yamashita; Y Shibata; E Kondo; Y Saito; M Taniguchi
Journal:  Proc Natl Acad Sci U S A       Date:  1999-06-22       Impact factor: 11.205

4.  PreTCR and TCRγδ signal initiation in thymocyte progenitors does not require domains implicated in receptor oligomerization.

Authors:  Juliet Mahtani-Patching; Joana F Neves; Dick John Pang; Kostadin V Stoenchev; Ana M Aguirre-Blanco; Bruno Silva-Santos; Daniel J Pennington
Journal:  Sci Signal       Date:  2011-07-19       Impact factor: 8.192

5.  Combined expression of pTalpha and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis.

Authors:  Diana Bellavia; Antonio F Campese; Saula Checquolo; Anna Balestri; Andrea Biondi; Giovanni Cazzaniga; Urban Lendahl; Hans J Fehling; Adrian C Hayday; Luigi Frati; Harald von Boehmer; Alberto Gulino; Isabella Screpanti
Journal:  Proc Natl Acad Sci U S A       Date:  2002-03-12       Impact factor: 11.205

6.  Mutation in the TCRα subunit constant gene (TRAC) leads to a human immunodeficiency disorder characterized by a lack of TCRαβ+ T cells.

Authors:  Neil V Morgan; Sarah Goddard; Tony S Cardno; David McDonald; Fatimah Rahman; Dawn Barge; Andrew Ciupek; Anna Straatman-Iwanowska; Shanaz Pasha; Mary Guckian; Graham Anderson; Aarnoud Huissoon; Andrew Cant; Warren P Tate; Sophie Hambleton; Eamonn R Maher
Journal:  J Clin Invest       Date:  2011-01-04       Impact factor: 14.808

7.  Expression of the mouse pre-T cell receptor alpha gene is controlled by an upstream region containing a transcriptional enhancer.

Authors:  B Reizis; P Leder
Journal:  J Exp Med       Date:  1999-05-17       Impact factor: 14.307

8.  Characterization of T cell differentiation in the murine gut.

Authors:  Florence Lambolez; Orly Azogui; Anne-Marie Joret; Corinne Garcia; Harald von Boehmer; James Di Santo; Sophie Ezine; Benedita Rocha
Journal:  J Exp Med       Date:  2002-02-18       Impact factor: 14.307

9.  Major T cell progenitor activity in bone marrow-derived spleen colonies.

Authors:  Christophe Lancrin; Elke Schneider; Florence Lambolez; Marie-Laure Arcangeli; Corinne Garcia-Cordier; Benedita Rocha; Sophie Ezine
Journal:  J Exp Med       Date:  2002-04-01       Impact factor: 14.307

10.  Constitutive activation of NF-kappaB and T-cell leukemia/lymphoma in Notch3 transgenic mice.

Authors:  D Bellavia; A F Campese; E Alesse; A Vacca; M P Felli; A Balestri; A Stoppacciaro; C Tiveron; L Tatangelo; M Giovarelli; C Gaetano; L Ruco; E S Hoffman; A C Hayday; U Lendahl; L Frati; A Gulino; I Screpanti
Journal:  EMBO J       Date:  2000-07-03       Impact factor: 11.598
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