Literature DB >> 96468

Lysergic acid diethylamide antagonizes shaking induced in rats by five chemically different compounds.

A Cowan, T Watson.   

Abstract

Thyrotropin-releasing hormone (TRH), sodium valproate, AF-3-5 (1-[2-hydroxyphenyl]-4-[3-nitrophenyl]-1,2,3,6-tetrahydropyrimidine-2-one), RX336-M (7,8-dihydro-5',6'-dimethylcyclohex-5'-eno-1',2',8',14 codeinone), and Sgd 8473 (alpha-[4-chlorobenzylideneamino)-oxy]-isobutyric acid) each induced repetitive shaking of the body of rats after intraperitoneal injection. This action of the five diverse chemicals appears to be subserved by a common pharmacological component, because pretreatment with d-lysergic acid diethylamide (0.03--1.0 mg kg-1, s.c.) attenuated the shaking behavior in a dose-related manner, and cross tolerance was found between RX336-M and TRH, sodium valproate, and AG-3-5.

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Year:  1978        PMID： 96468     DOI： 10.1007/bf00426956

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  27 in total

1.  Morphone abstinence and quasi-abstinence effects after phosphodiesterase inhibitors and naloxone.

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Authors:  W H Gispen; V M Wiegant; A F Bradbury; E C Hulme; D G Smyth; C R Snell; D de Wied
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5.  The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog.

Authors:  W R Martin; C G Eades; J A Thompson; R E Huppler; P E Gilbert
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6.  LSD as an agonist at mesolimbic dopamine receptors.

Authors:  P H Kelly; L L Iversen
Journal:  Psychopharmacologia       Date:  1975-12-31

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Journal:  Experientia       Date:  1968-07-15

8.  Effect of morphine antagonists on drug-induced hypothermia in mice and rats.

Authors:  A Cowan; I R Macfarlane
Journal:  Psychopharmacologia       Date:  1976-02-02

Review 9.  Sodium valproate: a review of its pharmacological properties and therapeutic efficacy in epilepsy.

Authors:  R M Pinder; R N Brogden; T M Speight; G S Avery
Journal:  Drugs       Date:  1977-02       Impact factor: 9.546

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Authors:  J W Lance; M Anthony
Journal:  Arch Neurol       Date:  1977-01
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  6 in total

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6.  Di-n-propylacetate-induced abstinence behaviour as a possible correlate of increased GABA-ergic activity in the rat.

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  6 in total

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