Literature DB >> 96459

Effects of perphenazine enanthate injections on prolactin levels in plasma from schizophrenic women and men.

H Lindholm, B Gullberg, A Ohman, G Sedvall.   

Abstract

Levels of prolactin (PRL) in plasma were determined in schizophrenic women and men after i.m. injections of 50-150 mg perphenazine enanthate (PE). In both sexes PRL levels increased dose-dependently. In men the effect was significant for 2 and in women for 9 days. Biperiden treatment did not influence the effect of PE on the PRL levels. The data support the view that clinically used doses of PE induce a small but significant blockade of central dopamine receptors.

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Year:  1978        PMID： 96459     DOI： 10.1007/bf00426949

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  11 in total

1.  EFFECT OF CHLORPROMAZINE OR HALOPERIDOL ON FORMATION OF 3METHOXYTYRAMINE AND NORMETANEPHRINE IN MOUSE BRAIN.

Authors:  A CARLSSON; M LINDQVIST
Journal:  Acta Pharmacol Toxicol (Copenh)       Date:  1963

2.  Clinical significance of plasma chlorpromazine levels. II. Plasma levels of the drug, some of its metabolites and prolactin in patients receiving long-term phenothiazine treatment.

Authors:  T Kolakowska; D H Wiles; M G Gelder; A S McNeilly
Journal:  Psychopharmacology (Berl)       Date:  1976-08-26       Impact factor: 4.530

3.  A rating scale for extrapyramidal side effects.

Authors:  G M Simpson; J W Angus
Journal:  Acta Psychiatr Scand Suppl       Date:  1970

4.  Effect of chlorpromazine on accumulation and disappearance of catecholamines formed from tyrosine-C14 in brain.

Authors:  H Nybäck; G Sedvall
Journal:  J Pharmacol Exp Ther       Date:  1968-08       Impact factor: 4.030

5.  Antipsychotic drugs stimulate prolactin release.

Authors:  J A Clemens; E B Smalstig; B D Sawyer
Journal:  Psychopharmacologia       Date:  1974

6.  The effect of neuroleptics on serum prolactin in schizophrenic patients.

Authors:  H Y Meltzer; V S Fang
Journal:  Arch Gen Psychiatry       Date:  1976-03

7.  The significance of dopamine-receptor blockade for the mechanism of action of neuroleptic drugs.

Authors:  J M van Rossum
Journal:  Arch Int Pharmacodyn Ther       Date:  1966-04

8.  Determination of perphenazine and its sulphoxide metabolite in human plasma after therapeutic doses by gas chromatography.

Authors:  N E Larsen; J Naestoft
Journal:  J Chromatogr       Date:  1975-06-18

9.  Clinical pharmacokinetic studies of perphenazine.

Authors:  C Eggert Hansen; T Rosted Christensen; J Elley; L Bolvig Hansen; P Kragh-Sorensen; N E Larsen; J Naestoft; E F Hvidberg
Journal:  Br J Clin Pharmacol       Date:  1976-10       Impact factor: 4.335

10.  Effect of chlorpromazine treatment on prolactin levels in cerebrospinal fluid and plasma of psychotic patients.

Authors:  B Wode-Helgodt; P Eneroth; B Fyrö; B Gullberg; G Sedvall
Journal:  Acta Psychiatr Scand       Date:  1977-10       Impact factor: 6.392
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  3 in total

Review 1.  Perphenazine for schizophrenia.

Authors:  Benno Hartung; Stephanie Sampson; Stefan Leucht
Journal:  Cochrane Database Syst Rev       Date:  2015-03-06

Review 2.  Depot perphenazine decanoate and enanthate for schizophrenia.

Authors:  A David; S Quraishi; J Rathbone
Journal:  Cochrane Database Syst Rev       Date:  2005-07-20

3.  A preliminary study of sex-related differences in prolactin responses to dopamine blockade and insulin hypoglycemia and in penfluridol plasma levels in schizophrenic patients.

Authors:  R S Nathan; E J Sachar; L Ostrow; G M Asnis; U Halbreich; F Halpern; N L Renzi; V Slotnick
Journal:  Psychopharmacology (Berl)       Date:  1983       Impact factor: 4.530
  3 in total

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