Literature DB >> 9645468

The murine gap junction gene connexin36 is highly expressed in mouse retina and regulated during brain development.

G Söhl1, J Degen, B Teubner, K Willecke.   

Abstract

A new gap junction gene isolated from rat brain cDNA, mouse retina cDNA and mouse genomic DNA is called connexin36, since it codes for a connexin protein of 321 amino acids corresponding to the theoretical molecular mass of 36045 kDa (rat) and 36084 kDa (mouse). Only one amino acid residue differs between rat and mouse connexin36. In the single murine connexin36 gene, an 1.14-kb intron interrupts the coding region, similar as in the homologous skate connexin35 gene. Because of this unique feature, mouse connexin36 differs from the other 13 murine connexin genes and is suggested to form a new delta subclass of connexins. Connexin36 mRNA (2.9 kb) is highly expressed in adult retina and less abundant in brain where it gradually increased during fetal development until day 7 post partum, and decreased thereafter.

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Year:  1998        PMID： 9645468     DOI： 10.1016/s0014-5793(98)00479-7

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  61 in total

1.  Synthesis and assembly of connexins in vitro into homomeric and heteromeric functional gap junction hemichannels.

Authors:  S Ahmad; J A Diez; C H George; W H Evans
Journal:  Biochem J       Date:  1999-04-15       Impact factor: 3.857

2.  Connexin expression in electrically coupled postnatal rat brain neurons.

Authors:  L Venance; A Rozov; M Blatow; N Burnashev; D Feldmeyer; H Monyer
Journal:  Proc Natl Acad Sci U S A       Date:  2000-08-29       Impact factor: 11.205

3.  Functional expression of the murine connexin 36 gene coding for a neuron-specific gap junctional protein.

Authors:  B Teubner; J Degen; G Söhl; M Güldenagel; F F Bukauskas; E B Trexler; V K Verselis; C I De Zeeuw; C G Lee; C A Kozak; E Petrasch-Parwez; R Dermietzel; K Willecke
Journal:  J Membr Biol       Date:  2000-08-01       Impact factor: 1.843

4.  Electrical transmission between mammalian neurons is supported by a small fraction of gap junction channels.

Authors:  Sebastian Curti; Gregory Hoge; James I Nagy; Alberto E Pereda
Journal:  J Membr Biol       Date:  2012-06-24       Impact factor: 1.843

5.  Evidence for connexin36 localization at hippocampal mossy fiber terminals suggesting mixed chemical/electrical transmission by granule cells.

Authors:  James I Nagy
Journal:  Brain Res       Date:  2012-07-06       Impact factor: 3.252

Review 6.  Novel model for the mechanisms of glutamate-dependent excitotoxicity: role of neuronal gap junctions.

Authors:  Andrei B Belousov
Journal:  Brain Res       Date:  2012-07-05       Impact factor: 3.252

Review 7.  The role of connexins during early embryonic development: pluripotent stem cells, gene editing, and artificial embryonic tissues as tools to close the knowledge gap.

Authors:  Philipp Wörsdörfer; Nicole Wagner; Süleyman Ergün
Journal:  Histochem Cell Biol       Date:  2018-07-23       Impact factor: 4.304

Review 8.  New insights into the role of connexins in pancreatic islet function and diabetes.

Authors:  Nikki L Farnsworth; Richard K P Benninger
Journal:  FEBS Lett       Date:  2014-02-28       Impact factor: 4.124

9.  Regulation of neuronal connexin-36 channels by pH.

Authors:  Daniel González-Nieto; Juan M Gómez-Hernández; Belén Larrosa; Cristina Gutiérrez; María D Muñoz; Ilaria Fasciani; John O'Brien; Agata Zappalà; Federico Cicirata; Luis C Barrio
Journal:  Proc Natl Acad Sci U S A       Date:  2008-10-28       Impact factor: 11.205

10.  In vivo labeling of parvalbumin-positive interneurons and analysis of electrical coupling in identified neurons.

Authors:  Axel H Meyer; István Katona; Maria Blatow; Andrei Rozov; Hannah Monyer
Journal:  J Neurosci       Date:  2002-08-15       Impact factor: 6.167
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