| Literature DB >> 9644976 |
M J Warren1, J B Cooper, S P Wood, P M Shoolingin-Jordan.
Abstract
In mammals and yeast, 5-aminolaevulinic acid dehydratase is a zinc-dependent enzyme that catalyses the synthesis of porphobilinogen-the pyrrole building block that is incorporated into all modified tetrapyrroles, including haem, chlorophyll and vitamin B12. The X-ray structure of this enzyme reveals how substitution of the catalytically important zinc ion by lead inactivates the enzyme and causes a form of pseudo-porphyria.Entities:
Mesh：
Substances：
Year: 1998 PMID： 9644976 DOI： 10.1016/s0968-0004(98)01219-5
Source DB: PubMed Journal: Trends Biochem Sci ISSN： 0968-0004 Impact factor: 13.807