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Literature DB >> 9644192

The cytochromes P450 and mechanisms of chemical carcinogenesis.

Abstract

This article reviews mechanisms of chemical carcinogenesis, from metabolic activation and generation of reactive oxygen species by cytochromes P4511 and P4502E to DNA damage, activation of protein kinase C and ocogenes, hyperplasia, and proteoglycan changes in the cell glycocalyx and lysosomal enzymes which mediate invasion and metastasis.

Entities: Chemical Disease Mutation

Mesh：

Substances：

Year: 1994 PMID： 9644192 PMCID： PMC1567360 DOI： 10.1289/ehp.94102852

Source DB: PubMed Journal: Environ Health Perspect ISSN： 0091-6765 Impact factor: 9.031

28 in total

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Authors: F P Guengerich
Journal: Life Sci Date: 1992 Impact factor: 5.037

2. Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects.

Authors: F P Guengerich; D H Kim; M Iwasaki
Journal: Chem Res Toxicol Date: 1991 Mar-Apr Impact factor: 3.739

3. The role of tumor-cell surface carbohydrate in experimental metastasis.

Authors: D R Stanford; J R Starkey; J A Magnuson
Journal: Int J Cancer Date: 1986-03-15 Impact factor: 7.396

4. Participation of rat liver cytochrome P450 2E1 in the activation of N-nitrosodimethylamine and N-nitrosodiethylamine to products genotoxic in an acetyltransferase-overexpressing Salmonella typhimurium strain (NM2009).

Authors: H Yamazaki; Y Oda; Y Funae; S Imaoka; Y Inui; F P Guengerich; T Shimada
Journal: Carcinogenesis Date: 1992-06 Impact factor: 4.944

5. Differential glycosylation and cell surface expression of lysosomal membrane glycoproteins in sublines of a human colon cancer exhibiting distinct metastatic potentials.

Authors: O Saitoh; W C Wang; R Lotan; M Fukuda
Journal: J Biol Chem Date: 1992-03-15 Impact factor: 5.157

Review 6. Genotoxicity of singlet oxygen.

Authors: B Epe
Journal: Chem Biol Interact Date: 1991 Impact factor: 5.192

7. Effect of cancer-related and drug-induced alterations in surface carbohydrates on the invasive capacity of mouse and rat cells.

Authors: J G Bolscher; D C Schallier; L A Smets; H van Rooy; J G Collard; E A Bruyneel; M M Mareel
Journal: Cancer Res Date: 1986-08 Impact factor: 12.701

Review 8. Active oxygen species as factors in multistage carcinogenesis.

Authors: G Witz
Journal: Proc Soc Exp Biol Med Date: 1991-11

Review 9. Endogenous mutagens and the causes of aging and cancer.

Authors: B N Ames; L S Gold
Journal: Mutat Res Date: 1991 Sep-Oct Impact factor: 2.433

10. Rat liver microsomal NADPH-supported oxidase activity and lipid peroxidation dependent on ethanol-inducible cytochrome P-450 (P-450IIE1).

Authors: G Ekström; M Ingelman-Sundberg
Journal: Biochem Pharmacol Date: 1989-04-15 Impact factor: 5.858

12 in total

Review 1. Does oxidative stress participate in the development of hepatocellular carcinoma?

Authors: Yutaka Sasaki
Journal: J Gastroenterol Date: 2007-02-06 Impact factor: 7.527

2. Metabolic activation of polycyclic aromatic hydrocarbons and aryl and heterocyclic amines by human cytochromes P450 2A13 and 2A6.

Authors: Tsutomu Shimada; Norie Murayama; Hiroshi Yamazaki; Katsuhiro Tanaka; Shigeo Takenaka; Masayuki Komori; Donghak Kim; F Peter Guengerich
Journal: Chem Res Toxicol Date: 2013-03-13 Impact factor: 3.739

3. Chronic unpredictable stress exacerbates 7,12-dimethylbenz (a) anthracene induced hepatotoxicity and nephrotoxicity in Swiss albino mice.

Authors: Nida Suhail; Nayeem Bilal; Shirin Hasan; Naheed Banu
Journal: Mol Cell Biochem Date: 2011-05-01 Impact factor: 3.396

4. Interactions between cigarette smoking and selected polymorphisms in xenobiotic metabolizing enzymes in risk for colorectal cancer: A case-only analysis.

Authors: Mala Pande; Christopher I Amos; Cathy Eng; Marsha L Frazier
Journal: Mol Carcinog Date: 2010-11 Impact factor: 4.784

5. Quantitative structure-activity relationships (QSARs) within the cytochrome P450 system: QSARs describing substrate binding, inhibition and induction of P450s.

Authors: David F V Lewis
Journal: Inflammopharmacology Date: 2003 Impact factor: 4.473

6. Personal reflections on 50 years of study of benzene toxicology.

Authors: D V Parke
Journal: Environ Health Perspect Date: 1996-12 Impact factor: 9.031

7. COMPACT and molecular structure in toxicity assessment: a prospective evaluation of 30 chemicals currently being tested for rodent carcinogenicity by the NCI/NTP.

Authors: D F Lewis; C Ioannides; D V Parke
Journal: Environ Health Perspect Date: 1996-10 Impact factor: 9.031