| Literature DB >> 9644071 |
K Y Jung1, D S Kim, S R Oh, S H Park, I S Lee, J J Lee, D H Shin, H K Lee.
Abstract
In a search for platelet-activating-factor (PAF) antagonists, two new lignan compounds were isolated from the Chinese crude drug shin-i, the flower buds of Magnolia fargesii. Their structures were elucidated as (2S,3R,4R)-tetrahydro-2-(3,4-dimethoxyphenyl)-4-(3, 4-dimethoxybenzoyl)-3-(hydroxymethyl)furan (magnone A, 1) and (2S,3R, 4R)-tetrahydro-2-(3,4,5-trimethoxyphenyl)-4-(3, 4-dimethoxybenzoyl)-3-(hydroxymethyl)furan (magnone B, 2). Magnones A and B showed antagonistic activity against PAF in the [3H]PAF receptor binding assay with the IC50 values of 3.8 x 10(-5) M and 2.7 x 10(-5) M, respectively.Entities:
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Year: 1998 PMID： 9644071 DOI： 10.1021/np970445+
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050