Literature DB >> 9644066

Epolones: novel sesquiterpene-tropolones from fungus OS-F69284 that induce erythropoietin in human cells.

P Cai1, D Smith, B Cunningham, S Brown-Shimer, B Katz, C Pearce, D Venables, D Houck.   

Abstract

In the course of our screening for small molecule modulators of erythropoietin gene expression, two novel sesquiterpene tropolones and pycnidone were isolated from a culture of OS-F69284 (ATCC 74390). Their structures were elucidated by extensive 1H and 13C NMR spectroscopic studies and chemical reactions. These compounds induced erythropoietin gene expression 5-fold at a concentration of 1-1.6 microM.

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Year:  1998        PMID： 9644066     DOI： 10.1021/np9800506

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  11 in total

1.  Enzymatic Intermolecular Hetero-Diels-Alder Reaction in the Biosynthesis of Tropolonic Sesquiterpenes.

Authors:  Qibin Chen; Jie Gao; Cooper Jamieson; Jiawang Liu; Masao Ohashi; Jian Bai; Daojian Yan; Bingyu Liu; Yongsheng Che; Yanan Wang; K N Houk; Youcai Hu
Journal:  J Am Chem Soc       Date:  2019-09-03       Impact factor: 15.419

Review 2.  Adaptive cellular stress pathways as therapeutic targets of dietary phytochemicals: focus on the nervous system.

Authors:  Jaewon Lee; Dong-Gyu Jo; Daeui Park; Hae Young Chung; Mark P Mattson
Journal:  Pharmacol Rev       Date:  2014-07       Impact factor: 25.468

3.  Genetic, molecular, and biochemical basis of fungal tropolone biosynthesis.

Authors:  Jack Davison; Ahmed al Fahad; Menghao Cai; Zhongshu Song; Samar Y Yehia; Colin M Lazarus; Andrew M Bailey; Thomas J Simpson; Russell J Cox
Journal:  Proc Natl Acad Sci U S A       Date:  2012-04-16       Impact factor: 11.205

Review 4.  Natural products from thioester reductase containing biosynthetic pathways.

Authors:  Michael W Mullowney; Ryan A McClure; Matthew T Robey; Neil L Kelleher; Regan J Thomson
Journal:  Nat Prod Rep       Date:  2018-09-19       Impact factor: 13.423

Review 5.  Natural product-derived small molecule activators of hypoxia-inducible factor-1 (HIF-1).

Authors:  Dale G Nagle; Yu-Dong Zhou
Journal:  Curr Pharm Des       Date:  2006       Impact factor: 3.116

6.  Total Synthesis and Computational Investigations of Sesquiterpene-Tropolones Ameliorate Stereochemical Inconsistencies and Resolve an Ambiguous Biosynthetic Relationship.

Authors:  Christopher Y Bemis; Chad N Ungarean; Alexander S Shved; Cooper S Jamieson; Taehwan Hwang; Ken S Lee; K N Houk; David Sarlah
Journal:  J Am Chem Soc       Date:  2021-04-07       Impact factor: 16.383

Review 7.  Harnessing ortho-Quinone Methides in Natural Product Biosynthesis and Biocatalysis.

Authors:  Trevor N Purdy; Bradley S Moore; April L Lukowski
Journal:  J Nat Prod       Date:  2022-02-02       Impact factor: 4.803

8.  Sea foam as a source of fungal inoculum for the isolation of biologically active natural products.

Authors:  David P Overy; Fabrice Berrue; Hebelin Correa; Novriyandi Hanif; Kathryn Hay; Martin Lanteigne; Kathrine Mquilian; Stephanie Duffy; Patricia Boland; Ramesh Jagannathan; Gavin S Carr; Marieke Vansteeland; Russell G Kerr
Journal:  Mycology       Date:  2014-07-09

9.  Metabolites with Anti-Inflammatory Activity from the Mangrove Endophytic Fungus Diaporthe sp. QYM12.

Authors:  Yan Chen; Ge Zou; Wencong Yang; Yingying Zhao; Qi Tan; Lin Chen; Jinmei Wang; Changyang Ma; Wenyi Kang; Zhigang She
Journal:  Mar Drugs       Date:  2021-01-24       Impact factor: 5.118

10.  Three previously unrecognised classes of biosynthetic enzymes revealed during the production of xenovulene A.

Authors:  Raissa Schor; Carsten Schotte; Daniel Wibberg; Jörn Kalinowski; Russell J Cox
Journal:  Nat Commun       Date:  2018-05-17       Impact factor: 14.919
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