BACKGROUND: Nitric oxide (NO) gas concentrations are high in the expired air of individuals with asthma, but not consistently so in the expired air of people with pneumonia. S-nitrosothiols are naturally occurring bronchodilators, the concentrations of which are raised in the airways of patients with pneumonia. Airway S-nitrosothiols have not been studied in asthma. METHODS: Tracheal S-nitrosothiol concentrations from eight asthmatic children in respiratory failure were compared with those of 21 children undergoing elective surgery. RESULTS: Mean S-nitrosothiol concentrations in asthmatic children were lower than in normal children (65 [SD 45] nmol/L vs 502 [SD 429] nmol/L) and did not vary with inspired oxygen concentration or airway thiol concentration. INTERPRETATION: Severe asthma is associated with low concentrations of airway S-nitrosothiols. This is the first reported deficiency of an endogenous bronchodilator in the human asthmatic airway lining fluid. We suggest that S-nitrosothiol metabolism may be a target for the development of new asthma therapies.
BACKGROUND:Nitric oxide (NO) gas concentrations are high in the expired air of individuals with asthma, but not consistently so in the expired air of people with pneumonia. S-nitrosothiols are naturally occurring bronchodilators, the concentrations of which are raised in the airways of patients with pneumonia. Airway S-nitrosothiols have not been studied in asthma. METHODS: Tracheal S-nitrosothiol concentrations from eight asthmatic children in respiratory failure were compared with those of 21 children undergoing elective surgery. RESULTS: Mean S-nitrosothiol concentrations in asthmatic children were lower than in normal children (65 [SD 45] nmol/L vs 502 [SD 429] nmol/L) and did not vary with inspired oxygen concentration or airway thiol concentration. INTERPRETATION: Severe asthma is associated with low concentrations of airway S-nitrosothiols. This is the first reported deficiency of an endogenous bronchodilator in the human asthmatic airway lining fluid. We suggest that S-nitrosothiol metabolism may be a target for the development of new asthma therapies.
Authors: Nadzeya V Marozkina; Sean Yemen; Molly Borowitz; Lei Liu; Melissa Plapp; Fei Sun; Rafique Islam; Petra Erdmann-Gilmore; R Reid Townsend; Cheryl F Lichti; Sneha Mantri; Phillip W Clapp; Scott H Randell; Benjamin Gaston; Khalequz Zaman Journal: Proc Natl Acad Sci U S A Date: 2010-06-08 Impact factor: 11.205
Authors: Shweta Choudhry; Loretta G Que; Zhonghui Yang; Limin Liu; Celeste Eng; Sung O Kim; Gunjan Kumar; Shannon Thyne; Rocio Chapela; Jose R Rodriguez-Santana; William Rodriguez-Cintron; Pedro C Avila; Jonathan S Stamler; Esteban G Burchard Journal: Pharmacogenet Genomics Date: 2010-06 Impact factor: 2.089
Authors: M P Moya; A J Gow; T J McMahon; E J Toone; I M Cheifetz; R N Goldberg; J S Stamler Journal: Proc Natl Acad Sci U S A Date: 2001-04-24 Impact factor: 11.205
Authors: Nicholas J Kettenhofen; Katarzyna A Broniowska; Agnes Keszler; Yanhong Zhang; Neil Hogg Journal: J Chromatogr B Analyt Technol Biomed Life Sci Date: 2007-02-25 Impact factor: 3.205
Authors: Khalequz Zaman; Marie H Hanigan; Alison Smith; John Vaughan; Timothy Macdonald; David R Jones; John F Hunt; Benjamin Gaston Journal: Am J Respir Cell Mol Biol Date: 2006-01-13 Impact factor: 6.914
Authors: Raed A Dweik; Ronald L Sorkness; Sally Wenzel; Jeffrey Hammel; Douglas Curran-Everett; Suzy A A Comhair; Eugene Bleecker; William Busse; William J Calhoun; Mario Castro; Kian Fan Chung; Elliot Israel; Nizar Jarjour; Wendy Moore; Stephen Peters; Gerald Teague; Benjamin Gaston; Serpil C Erzurum Journal: Am J Respir Crit Care Med Date: 2010-02-04 Impact factor: 21.405