Current status of genetic discoveries in migraine: familial hemiplegic migraine and beyond.

Familial hemiplegic migraine (FHM) has been related to mutations in a brain calcium channel gene among Chr19p linked FHM families. Subsequent genetic Studies in different FHM families showed that additional causative genes must reside in other regions of the genome, including the long arm of Chromosome 1. Parallel discoveries in mouse mutants involving ion channel genes have also accelerated our understanding of the spectrum and functional significance of the CNS-related ion channel disorders. These studies have clear implications for migraine, epilepsy, and ataxia. An association study was suggested that other 'susceptibility' genes like the dopamine DRD2 receptor will be important in characterizing the genetic components of the larger, heterogeneous group of migraine disorders.