| Literature DB >> 9640538 |
M Bienz1.
Abstract
T cell factor, or TCF, has been identified as the transcriptional response factor activated by Wnt-1 and Wingless signalling. TCF is thought to be a potent architectural factor which facilitates assembly of multiprotein enhancer complexes. Its deregulation in the colonic epithelium, and in other cells, leads to cancer. This raises the question of how TCF is kept inactive in unstimulated cells.Entities:
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Year: 1998 PMID： 9640538 DOI： 10.1016/s0955-0674(98)80013-6
Source DB: PubMed Journal: Curr Opin Cell Biol ISSN： 0955-0674 Impact factor: 8.382