Literature DB >> 9640533

Telomeres, the nucleolus and aging.

F B Johnson1, R A Marciniak, L Guarente.   

Abstract

Reactivation of telomerase in cultured human cells extends their replicative life span beyond the Hayflick limit. How telomere shortening triggers cell senescence and whether it contributes to aging in vivo are under investigation. Studies in yeast have revealed another site critical to cellular aging: the nucleolus. The accumulation of ribosomal DNA circles is a cause of aging in this organism. The possible relevance of this mechanism to human aging is also being considered.

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Year:  1998        PMID： 9640533     DOI： 10.1016/s0955-0674(98)80008-2

Source DB:  PubMed          Journal:  Curr Opin Cell Biol        ISSN： 0955-0674            Impact factor:   8.382


  15 in total

1.  Unique motif for nucleolar retention and nuclear export regulated by phosphorylation.

Authors:  Frédéric Catez; Monique Erard; Nathalie Schaerer-Uthurralt; Karine Kindbeiter; Jean-Jacques Madjar; Jean-Jacques Diaz
Journal:  Mol Cell Biol       Date:  2002-02       Impact factor: 4.272

2.  Functional proteomic analysis of human nucleolus.

Authors:  Alexander Scherl; Yohann Couté; Catherine Déon; Aleth Callé; Karine Kindbeiter; Jean-Charles Sanchez; Anna Greco; Denis Hochstrasser; Jean-Jacques Diaz
Journal:  Mol Biol Cell       Date:  2002-11       Impact factor: 4.138

3.  Daughters of the budding yeast from old mothers have shorter replicative lifespans but not total lifespans. Are DNA damage and rDNA instability the factors that determine longevity?

Authors:  Mateusz Molon; Anita Panek; Eliza Molestak; Marek Skoneczny; Marek Tchorzewski; Maciej Wnuk
Journal:  Cell Cycle       Date:  2018-07-15       Impact factor: 4.534

Review 4.  Nucleolus, ribosomes, and cancer.

Authors:  Lorenzo Montanaro; Davide Treré; Massimo Derenzini
Journal:  Am J Pathol       Date:  2008-06-26       Impact factor: 4.307

5.  Opposing role of condensin and radiation-sensitive gene RAD52 in ribosomal DNA stability regulation.

Authors:  Chi Kwan Tsang; X F Steven Zheng
Journal:  J Biol Chem       Date:  2009-06-11       Impact factor: 5.157

6.  Mitotic cyclins regulate telomeric recombination in telomerase-deficient yeast cells.

Authors:  Nathalie Grandin; Michel Charbonneau
Journal:  Mol Cell Biol       Date:  2003-12       Impact factor: 4.272

7.  Phosphorylation of nucleoporin Tpr governs its differential localization and is required for its mitotic function.

Authors:  Kalpana Rajanala; Anshuk Sarkar; Gagan Deep Jhingan; Raina Priyadarshini; Manisha Jalan; Sagar Sengupta; Vinay Kumar Nandicoori
Journal:  J Cell Sci       Date:  2014-06-17       Impact factor: 5.285

Review 8.  Nucleolar activity in neurodegenerative diseases: a missing piece of the puzzle?

Authors:  Rosanna Parlato; Grzegorz Kreiner
Journal:  J Mol Med (Berl)       Date:  2012-11-20       Impact factor: 4.599

Review 9.  Yeast mother cell-specific ageing, genetic (in)stability, and the somatic mutation theory of ageing.

Authors:  Peter Laun; Carlo V Bruschi; J Richard Dickinson; Mark Rinnerthaler; Gino Heeren; Richard Schwimbersky; Raphaela Rid; Michael Breitenbach
Journal:  Nucleic Acids Res       Date:  2007-11-06       Impact factor: 16.971

10.  Telomere and ribosomal DNA repeats are chromosomal targets of the bloom syndrome DNA helicase.

Authors:  James Schawalder; Enesa Paric; Norma F Neff
Journal:  BMC Cell Biol       Date:  2003-10-27       Impact factor: 4.241
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