Literature DB >> 9639803

Effects of cyclosporin A on proliferation of cultured rat mesangial cells.

J Sun1, Y Wang.   

Abstract

The proliferation of mesangial cells on cyclosporin (CsA) test medium was studied by MTT assay and TNF-alpha in cultured supernatant was examined by using ELISA. The results showed that cyclosporin A significantly inhibited the proliferation of mesangial cells at the concentration between 0.25-15 micrograms/ml (IC50 1 microgram). This action appeared to be dose-dependent. Release of TNF-alpha from mesangial cells stimulated by LPS was also dose-dependently suppressed. It is suggested that cyclosporin A play an important role in antiproliferation mechanism of mesangial cells in vitro.

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Year:  1997        PMID： 9639803     DOI： 10.1007/bf02888248

Source DB:  PubMed          Journal:  J Tongji Med Univ        ISSN： 0257-716X


  11 in total

Review 1.  Tumor necrosis factor alpha and mesangial cells.

Authors:  L Baud; B Fouqueray; C Philippe; A Amrani
Journal:  Kidney Int       Date:  1992-03       Impact factor: 10.612

Review 2.  Interleukin 1-alpha and tumor necrosis factor-alpha induce oxygen radical production in mesangial cells.

Authors:  H H Radeke; B Meier; N Topley; J Flöge; G G Habermehl; K Resch
Journal:  Kidney Int       Date:  1990-02       Impact factor: 10.612

3.  Improved methods for culturing rat glomerular cells.

Authors:  P A Harper; J M Robinson; R L Hoover; T C Wright; M J Karnovsky
Journal:  Kidney Int       Date:  1984-12       Impact factor: 10.612

4.  Production of tumor necrosis factor by rat mesangial cells in response to bacterial lipopolysaccharide.

Authors:  L Baud; J P Oudinet; M Bens; L Noe; M N Peraldi; E Rondeau; J Etienne; R Ardaillou
Journal:  Kidney Int       Date:  1989-05       Impact factor: 10.612

5.  Actions of cyclosporin A on cultured rat mesangial cells.

Authors:  D Rodríguez-Puyol; S Lamas; A Olivera; A López-Farré; G Ortega; L Hernando; J M López-Novoa
Journal:  Kidney Int       Date:  1989-02       Impact factor: 10.612

6.  Effects of cyclosporin and FK-506 on glomerular mesangial cells. Evidence for direct inhibition of thromboxane synthase by low cyclosporin concentrations.

Authors:  H H Radeke; S Kuster; V Kaever; K Resch
Journal:  Eur J Clin Pharmacol       Date:  1993       Impact factor: 2.953

7.  Tissue factor production by cultured rat mesangial cells. Stimulation by TNF alpha and lipopolysaccharide.

Authors:  R C Wiggins; N Njoku; J R Sedor
Journal:  Kidney Int       Date:  1990-05       Impact factor: 10.612

8.  [A ciclosporin A responsive case of Behçet's disease associated with IgA nephropathy].

Authors:  T Suemitsu; T Saga; A Inui; M Ariizumi; E Shogi; H Sato
Journal:  Nihon Jinzo Gakkai Shi       Date:  1993-02

9.  [The long-term effects of cyclosporine on cultured rat mesangial cell].

Authors:  S Wann; C Y Fan; T P Huang
Journal:  Zhonghua Yi Xue Za Zhi (Taipei)       Date:  1992-01

10.  Mesangioproliferative glomerulonephritis.

Authors:  L Migone; G Olivetti; L Allegri; P Dall'Aglio
Journal:  Clin Nephrol       Date:  1980-05       Impact factor: 0.975
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