Role of injury of gastric parietal vessels by immunocomplexes in the mechanism of gastric mucosal lesion in portal hypertension with cirrhosis.

The present experiment employed the immunohistochemical technique and morphological observation to investigate the expression and distribution of C3, C4, IgG, IgE 5-HT in portal hypertensive pigs with pathological change of gastric mucosa and gastric parietal vessels. The wall of gastric mucosal mirco-vessels in portal hypertensive pigs had a positive or strong positive reaction of C3, C4, IgG, IgE and 5-HT with obvious injury of gastric mucosa normal pigs imparted negative or feeble positive reaction, suggesting that during portal hypertension, the gastric mucosal micro-vessels has deposit of immunocomplexes resulting in the injury of the micro-vessels. It might be a factor involved in the pathogenesis of the gastric mucosal lesion during portal hypertension with cirrhosis.