Y Su1, S Hong, A Zhao. 1. Renji Hospital, Shanghai Second Medical University.
Abstract
OBJECTIVE: To determine the changes of T lymphocyte subsets, natural killer (NK) cell and serum interleukin-2 receptor (SIL-2R) in peripheral blood of the pregnant women with systemic lupus erythematosus (SLE). METHODS: T lymphocyte subsets NK cell, and SIL-2R in peripheral blood were detected by flow cytometry (FCM) and enzyme-labeled immunosorbent assay (ELISA) in 14 cases of pregnant women complicated by SLE (SLE+NP), 18 cases of stationary phase SLE (SLE), 20 cases of normal non-pregnant women (NNP) and 20 cases of normal pregnant women (NP). RESULTS: The percentages of CD4+ cell were decreased significantly in SLE+NP group as compared with the other three groups (P < 0.01); and the ratio of CD4+/CD8+ was decreased significantly in SLE+NP group, as compared that in SLE group and in NNP group (P < 0.01). There were no difference in the number of NK cells among the four groups. The SIL-2R values were found to be increased significantly in the SLE+NP group, as compared with that of other three groups (P < 0.01). CONCLUSION: The observation on the changes of peripheral T lymphocyte subsets and SIL-2R may be helpful for monitoring progress of SLE during pregnancy.
OBJECTIVE: To determine the changes of T lymphocyte subsets, natural killer (NK) cell and serum interleukin-2 receptor (SIL-2R) in peripheral blood of the pregnant women with systemic lupus erythematosus (SLE). METHODS: T lymphocyte subsets NK cell, and SIL-2R in peripheral blood were detected by flow cytometry (FCM) and enzyme-labeled immunosorbent assay (ELISA) in 14 cases of pregnant women complicated by SLE (SLE+NP), 18 cases of stationary phase SLE (SLE), 20 cases of normal non-pregnant women (NNP) and 20 cases of normal pregnant women (NP). RESULTS: The percentages of CD4+ cell were decreased significantly in SLE+NP group as compared with the other three groups (P < 0.01); and the ratio of CD4+/CD8+ was decreased significantly in SLE+NP group, as compared that in SLE group and in NNP group (P < 0.01). There were no difference in the number of NK cells among the four groups. The SIL-2R values were found to be increased significantly in the SLE+NP group, as compared with that of other three groups (P < 0.01). CONCLUSION: The observation on the changes of peripheral T lymphocyte subsets and SIL-2R may be helpful for monitoring progress of SLE during pregnancy.