Literature DB >> 9639555

The majority of human glutathione peroxidase type 5 (GPX5) transcripts are incorrectly spliced: implications for the role of GPX5 in the male reproductive tract.

L Hall1, K Williams, A C Perry, J Frayne, J A Jury.   

Abstract

An epididymis-specific, secretory glutathione peroxidase (GPX5) has been proposed previously to play a role in protecting mammalian sperm membranes from the deleterious effects of lipid peroxidation, which, if not contained, can lead to reduced fertilizing capacity. Here we report the cDNA cloning of human GPX5 and show that the majority of transcripts contain a 118 nt frame-shifting deletion, arising, most likely, from inappropriate excision of exon 3 during processing. Antisera raised against recombinant human GPX5 cross-reacted with rat and macaque (Macaca fascicularis) epididymal proteins of the size expected for full-length, active GPX5. However, no similar reactivity could be demonstrated in any of the human samples tested.

Entities:  

Mesh：

Substances：

Year:  1998        PMID： 9639555      PMCID： PMC1219548          DOI： 10.1042/bj3330005

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  12 in total

1.  Molecular cloning and characterization of the epididymis-specific glutathione peroxidase-like protein secreted in the porcine epididymal fluid.

Authors:  N Okamura; Y Iwaki; S Hiramoto; M Tamba; S Bannai; Y Sugita; P Syntin; F Dacheux; J L Dacheux
Journal:  Biochim Biophys Acta       Date:  1997-07-19

2.  Macaque MDC family of proteins: sequence analysis, tissue distribution and processing in the male reproductive tract.

Authors:  J Frayne; J A Jury; H L Barker; A C Perry; R Jones; L Hall
Journal:  Mol Hum Reprod       Date:  1998-05       Impact factor: 4.025

3.  In vitro expression of a mouse tissue specific glutathione-peroxidase-like protein lacking the selenocysteine can protect stably transfected mammalian cells against oxidative damage.

Authors:  P Vernet; N Rigaudiére; N Ghyselinck; J P Dufaure; J R Drevet
Journal:  Biochem Cell Biol       Date:  1996       Impact factor: 3.626

4.  Preparation of a plasma membrane-rich fraction from rat spermatozoa.

Authors:  R Jones
Journal:  J Reprod Fertil       Date:  1986-07

Review 5.  Biochemistry of the induction and prevention of lipoperoxidative damage in human spermatozoa.

Authors:  B T Storey
Journal:  Mol Hum Reprod       Date:  1997-03       Impact factor: 4.025

6.  Tissue and developmental distribution, dependence upon testicular factors and attachment to spermatozoa of GPX5, a murine epididymis-specific glutathione peroxidase.

Authors:  P Vernet; J Faure; J P Dufaure; J R Drevet
Journal:  Mol Reprod Dev       Date:  1997-05       Impact factor: 2.609

7.  Generation of reactive oxygen species, lipid peroxidation, and human sperm function.

Authors:  R J Aitken; J S Clarkson; S Fishel
Journal:  Biol Reprod       Date:  1989-07       Impact factor: 4.285

8.  Isolation and characterization of a rat cDNA clone encoding a secreted superoxide dismutase reveals the epididymis to be a major site of its expression.

Authors:  A C Perry; R Jones; L Hall
Journal:  Biochem J       Date:  1993-07-01       Impact factor: 3.857

9.  Genetic evidence for an androgen-regulated epididymal secretory glutathione peroxidase whose transcript does not contain a selenocysteine codon.

Authors:  A C Perry; R Jones; L S Niang; R M Jackson; L Hall
Journal:  Biochem J       Date:  1992-08-01       Impact factor: 3.857

10.  Structural organization and regulation of the gene for the androgen-dependent glutathione peroxidase-like protein specific to the mouse epididymis.

Authors:  N B Ghyselinck; I Dufaure; J J Lareyre; N Rigaudière; M G Mattéi; J P Dufaure
Journal:  Mol Endocrinol       Date:  1993-02
View more
  7 in total

Review 1.  The Intestinal Redox System and Its Significance in Chemotherapy-Induced Intestinal Mucositis.

Authors:  Qing-Qing Yu; Heng Zhang; Yujin Guo; Baoqin Han; Pei Jiang
Journal:  Oxid Med Cell Longev       Date:  2022-05-09       Impact factor: 7.310

2.  Altered antioxidant status and increased lipid per-oxidation in seminal plasma of tunisian infertile men.

Authors:  Fatma Atig; Monia Raffa; Habib Ben Ali; Kerkeni Abdelhamid; Ali Saad; Mounir Ajina
Journal:  Int J Biol Sci       Date:  2011-12-08       Impact factor: 6.580

3.  Seminal malondialdehyde concentration but not glutathione peroxidase activity is negatively correlated with seminal concentration and motility.

Authors:  Yao-Yuan Hsieh; Chi-Chen Chang; Chich-Sheng Lin
Journal:  Int J Biol Sci       Date:  2006-03-27       Impact factor: 6.580

Review 4.  The Architecture of Thiol Antioxidant Systems among Invertebrate Parasites.

Authors:  Alberto Guevara-Flores; José de Jesús Martínez-González; Juan Luis Rendón; Irene Patricia Del Arenal
Journal:  Molecules       Date:  2017-02-10       Impact factor: 4.411

5.  Peroxiredoxin 6 Peroxidase and Ca2+-Independent Phospholipase A2 Activities Are Essential to Support Male-Mouse Fertility.

Authors:  Edrian Bumanlag; Eleonora Scarlata; Cristian O'Flaherty
Journal:  Antioxidants (Basel)       Date:  2022-01-25

6.  Proteasome activators, PA28γ and PA200, play indispensable roles in male fertility.

Authors:  Lin Huang; Kousuke Haratake; Hatsumi Miyahara; Tomoki Chiba
Journal:  Sci Rep       Date:  2016-03-22       Impact factor: 4.379

Review 7.  ROS as Regulators of Cellular Processes in Melanoma.

Authors:  Isabella Venza; Mario Venza; Maria Visalli; Germana Lentini; Diana Teti; Francesco Stagno d'Alcontres
Journal:  Oxid Med Cell Longev       Date:  2021-10-23       Impact factor: 6.543
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.