Literature DB >> 9638405

Role of iron in the natural history and clinical course of hepatitis C disease.

S I Shedlofsky1.   

Abstract

The following review evaluates the current data implicating a role for hepatic iron in enhancing the liver injury in patients with chronic hepatitis C infection. Iron removal lowers transaminases, but doesn't appear to improve responsiveness to interferon-alpha therapy. An important effect of iron removal might be to delay progression of liver injury to fibrosis and cirrhosis. Until such a hypothesis is disproven, phlebotomy therapy for even mildly iron-loaded HCV patients is recommended.

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Year:  1998        PMID： 9638405

Source DB:  PubMed          Journal:  Hepatogastroenterology        ISSN： 0172-6390


  8 in total

1.  EGCG inhibit chemical reactivity of iron through forming an Ngal-EGCG-iron complex.

Authors:  Guan-Hu Bao; Jie Xu; Feng-Lin Hu; Xiao-Chun Wan; Shi-Xian Deng; Jonathan Barasch
Journal:  Biometals       Date:  2013-10-26       Impact factor: 2.949

2.  The natural course of hepatitis C virus infection after 22 years in a unique homogenous cohort: spontaneous viral clearance and chronic HCV infection.

Authors:  S Barrett; J Goh; B Coughlan; E Ryan; S Stewart; A Cockram; J C O'Keane; J Crowe
Journal:  Gut       Date:  2001-09       Impact factor: 23.059

3.  Effect of hepatic iron concentration reduction on hepatic fibrosis and damage in rats with cholestatic liver disease.

Authors:  Gil Peretz; Gabriela Link; Orit Pappo; Rafael Bruck; Zvi Ackerman
Journal:  World J Gastroenterol       Date:  2006-01-14       Impact factor: 5.742

4.  Hepatitis C virus encodes a selenium-dependent glutathione peroxidase gene. Implications for oxidative stress as a risk factor in progression to hepatocellular carcinoma.

Authors:  W Zhang; A G Cox; E W Taylor
Journal:  Med Klin (Munich)       Date:  1999-10-15

5.  Infections in thalassemia and hemoglobinopathies: focus on therapy-related complications.

Authors:  Bianca Maria Ricerca; Arturo Di Girolamo; Deborah Rund
Journal:  Mediterr J Hematol Infect Dis       Date:  2009-12-28       Impact factor: 2.576

6.  Effect of hepatic iron concentration and viral factors in chronic hepatitis C-infected patients with thalassemia major, treated with interferon and ribavirin.

Authors:  Maryam Jafroodi; Ramin Asadi; Abtin Heydarzadeh; Sepiedeh Besharati
Journal:  Int J Gen Med       Date:  2011-07-13

Review 7.  Oxidative Stress and Inflammation in Hepatic Diseases: Therapeutic Possibilities of N-Acetylcysteine.

Authors:  Kívia Queiroz de Andrade; Fabiana Andréa Moura; John Marques dos Santos; Orlando Roberto Pimentel de Araújo; Juliana Célia de Farias Santos; Marília Oliveira Fonseca Goulart
Journal:  Int J Mol Sci       Date:  2015-12-18       Impact factor: 5.923

Review 8.  Hepatoprotective Effects of Chinese Medicinal Herbs: A Focus on Anti-Inflammatory and Anti-Oxidative Activities.

Authors:  Puiyan Lam; Fan Cheung; Hor Yue Tan; Ning Wang; Man Fung Yuen; Yibin Feng
Journal:  Int J Mol Sci       Date:  2016-03-29       Impact factor: 5.923
  8 in total

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