Literature DB >> 9637789

In vivo effects of hepatocyte growth factor/scatter factor on mouse mammary gland development.

J Yant1, L Buluwela, B Niranjan, B Gusterson, T Kamalati.   

Abstract

We have recently demonstrated the regulated expression of HGF/SF and its receptor (c-met) during mouse mammary gland development together with the mitogenic, motogenic and morphogenic effects of exogenous HGF/SF on primary mammary epithelial cells in culture. This study was undertaken to analyze the influence of HGF/SF on reconstituted mouse mammary gland development in vivo. Here we report that overexpression of HGF/SF induces a range of alterations in the architecture of virgin mouse mammary gland. These include an enhancement of ductal end bud (mammary gland morphoregulatory control point) size and numbers and hyperplastic branching morphogenesis. These data are the first demonstration of the effects of HGF/SF on mammary epithelium in vivo. Copyright 1998 Academic Press.

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Year:  1998        PMID： 9637789     DOI： 10.1006/excr.1998.4028

Source DB:  PubMed          Journal:  Exp Cell Res        ISSN： 0014-4827            Impact factor:   3.905


  17 in total

Review 1.  HGF/SF in mammary epithelial growth and morphogenesis: in vitro and in vivo models.

Authors:  T Kamalati; B Niranjan; J Yant; L Buluwela
Journal:  J Mammary Gland Biol Neoplasia       Date:  1999-01       Impact factor: 2.673

2.  Adipose stroma induces branching morphogenesis of engineered epithelial tubules.

Authors:  Amira L Pavlovich; Sriram Manivannan; Celeste M Nelson
Journal:  Tissue Eng Part A       Date:  2010-08-30       Impact factor: 3.845

Review 3.  Comparative mechanisms of branching morphogenesis in diverse systems.

Authors:  Pengfei Lu; Mark D Sternlicht; Zena Werb
Journal:  J Mammary Gland Biol Neoplasia       Date:  2006-10       Impact factor: 2.673

4.  Down-regulation of the met receptor tyrosine kinase by presenilin-dependent regulated intramembrane proteolysis.

Authors:  Bénédicte Foveau; Frédéric Ancot; Catherine Leroy; Annalisa Petrelli; Karina Reiss; Valérie Vingtdeux; Silvia Giordano; Véronique Fafeur; David Tulasne
Journal:  Mol Biol Cell       Date:  2009-03-18       Impact factor: 4.138

5.  Biological roles of hepatocyte growth factor-Met signaling from genetically modified animals.

Authors:  Takashi Kato
Journal:  Biomed Rep       Date:  2017-10-18

6.  Mammary adipocytes bioactivate 25-hydroxyvitamin D₃ and signal via vitamin D₃ receptor, modulating mammary epithelial cell growth.

Authors:  Stephen Ching; Soumya Kashinkunti; Matthew D Niehaus; Glendon M Zinser
Journal:  J Cell Biochem       Date:  2011-11       Impact factor: 4.429

7.  Mammary branch initiation and extension are inhibited by separate pathways downstream of TGFβ in culture.

Authors:  Amira L Pavlovich; Eline Boghaert; Celeste M Nelson
Journal:  Exp Cell Res       Date:  2011-04-01       Impact factor: 3.905

8.  Stage-dependent regulation of mammary ductal branching by heparan sulfate and HGF-cMet signaling.

Authors:  Omai B Garner; Kevin T Bush; Kabir B Nigam; Yu Yamaguchi; Ding Xu; Jeffrey D Esko; Sanjay K Nigam
Journal:  Dev Biol       Date:  2011-05-07       Impact factor: 3.582

9.  The Ron receptor tyrosine kinase negatively regulates mammary gland branching morphogenesis.

Authors:  Sara E Meyer; Glendon M Zinser; William D Stuart; Peterson Pathrose; Susan E Waltz
Journal:  Dev Biol       Date:  2009-07-01       Impact factor: 3.582

10.  Progestin-regulated luminal cell and myoepithelial cell-specific responses in mammary organoid culture.

Authors:  Sandra Z Haslam; Alexis Drolet; Kyle Smith; May Tan; Mark Aupperlee
Journal:  Endocrinology       Date:  2008-01-24       Impact factor: 4.736
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