Literature DB >> 9637248

Minimal tRNA(Ser) and tRNA(Sec) substrates for human seryl-tRNA synthetase: contribution of tRNA domains to serylation and tertiary structure.

M Heckl1, K Busch, H J Gross.   

Abstract

The recognition process of tRNA(Ser) and tRNA(Sec) by human seryl-tRNA synthetase (SerRS) was studied using T7 transcripts representing defined regions of human tRNA(Ser) or tRNA(Sec) and the influence of the tRNA elements on serylation and tertiary structure was elucidated. The anticodon arms of both tRNAs showed no contribution to serylation in contrast to the acceptor stems and the long extra arms. D and T arms were only involved in formation of the L-shaped tRNA structure, not in the recognition process between tRNAs and SerRS. This is the first report of microhelices adapted from human tRNAs being aminoacylated by their homologous synthetase.

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Year:  1998        PMID： 9637248     DOI： 10.1016/s0014-5793(98)00435-9

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  9 in total

1.  Identification of a protein component of a mammalian tRNA(Sec) complex implicated in the decoding of UGA as selenocysteine.

Authors:  F Ding; P J Grabowski
Journal:  RNA       Date:  1999-12       Impact factor: 4.942

2.  Crystallization and preliminary X-ray diffraction analysis of human cytosolic seryl-tRNA synthetase.

Authors:  Jean Baptiste Artero; Susana C M Teixeira; Edward P Mitchell; Michael A Kron; V Trevor Forsyth; Michael Haertlein
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2010-10-29

3.  Identification of essential domains for Escherichia coli tRNA(leu) aminoacylation and amino acid editing using minimalist RNA molecules.

Authors:  Deana C Larkin; Amy M Williams; Susan A Martinis; George E Fox
Journal:  Nucleic Acids Res       Date:  2002-05-15       Impact factor: 16.971

4.  Enhanced detection of tRNA isoacceptors by combinatorial oligonucleotide hybridization.

Authors:  A Buvoli; M Buvoli; L A Leinwand
Journal:  RNA       Date:  2000-06       Impact factor: 4.942

5.  Complete set of orthogonal 21st aminoacyl-tRNA synthetase-amber, ochre and opal suppressor tRNA pairs: concomitant suppression of three different termination codons in an mRNA in mammalian cells.

Authors:  Caroline Köhrer; Eric L Sullivan; Uttam L RajBhandary
Journal:  Nucleic Acids Res       Date:  2004-12-01       Impact factor: 16.971

6.  Crystal structure of human Seryl-tRNA synthetase and Ser-SA complex reveals a molecular lever specific to higher eukaryotes.

Authors:  Xiaoling Xu; Yi Shi; Xiang-Lei Yang
Journal:  Structure       Date:  2013-10-03       Impact factor: 5.006

7.  Computational identification of the selenocysteine tRNA (tRNASec) in genomes.

Authors:  Didac Santesmasses; Marco Mariotti; Roderic Guigó
Journal:  PLoS Comput Biol       Date:  2017-02-13       Impact factor: 4.475

8.  Insights into substrate promiscuity of human seryl-tRNA synthetase.

Authors:  Kaitlyn M Holman; Anupama K Puppala; Jonathan W Lee; Hyun Lee; Miljan Simonović
Journal:  RNA       Date:  2017-08-14       Impact factor: 4.942

Review 9.  Naturally Occurring tRNAs With Non-canonical Structures.

Authors:  Natalie Krahn; Jonathan T Fischer; Dieter Söll
Journal:  Front Microbiol       Date:  2020-10-21       Impact factor: 5.640
  9 in total

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