| Literature DB >> 9635843 |
R A McClelland1, D L Manning, J M Gee, P Willsher, J F Robertson, I O Ellis, R W Blamey, R I Nicholson.
Abstract
Northern hybridization analyses of the oestrogen-inducible mRNAs pLIV1 and pS2 were compared with oestrogen receptor (ER) immunocytochemistry assessments in 40 untreated primary or early recurrent breast tumours. Significant associations were observed between pLIV1/ER (P < 0.03), pS2/ER (P < 0.001) and pLIV1/pS2 (P < 0.04) status. After disease recurrence, patients were treated with assessable courses of endocrine therapies. Positive pLIV1, pS2 and ER statuses in primary disease were consequently found to be predictive of endocrine responsiveness in the secondary lesions (P < 0.03, P < 0.02, P < 0.005 respectively). However, despite these associations, a number of pLIV1- and/or pS2-positive tumours failed to respond to therapy.Entities:
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Year: 1998 PMID： 9635843 PMCID： PMC2150074 DOI： 10.1038/bjc.1998.271
Source DB: PubMed Journal: Br J Cancer ISSN： 0007-0920 Impact factor: 7.640