| Literature DB >> 9634692 |
Abstract
The recently determined crystal structures of fragments of the human and vaccinia virus type IB topoisomerases reveal unexpected similarity with the lambda family of site-specific recombinases. The conservation of structure suggests a common mechanism, indicating that topoisomerase activity may be the consequence of uncoupling DNA strand cleavage/religation from synapsis.Entities:
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Year: 1998 PMID： 9634692 DOI： 10.1016/s0969-2126(98)00056-2
Source DB: PubMed Journal: Structure ISSN： 0969-2126 Impact factor: 5.006