BACKGROUND: We have previously reported the results of cerebral MRI examinations in an unselected year cohort of very low birth weight (VLBW) infants at one year of corrected age. Twenty-one (78 %) of 27 infants had abnormal myelination, mainly in the central occipital white matter (COWM) and in the centrum semiovale (CS), seen on T2-weighted images. Twelve infants had irregular and dilated lateral ventricles. We speculated whether these findings indicated perinatal periventricular leukomalacia (PVL). Only two infants had completely normal MRI at age 1 year. OBJECTIVE: To determine whether the abnormal myelination seen at 1 year of age, was still present, either as delayed myelination or as gliosis caused by perinatal PVL. MATERIALS AND METHODS: In the present study, we report the results of follow-up cerebral MRI in 20 of these infants at 6 years of age. RESULTS: Most of the children with MRI deviations at 1 year still had abnormalities at 6 years. Abnormal myelination in the central occipital white matter combined with abnormalities in the CS or with ventricular dilatation at age 1 year, presented as gliosis in 12 of 13 children at 6 years of age. Abnormalities solely in the COWM at age 1 year had normalised in two of five children and persisted as delayed myelination in three at age 6 years. Gliotic changes in periventricular white matter were found in 12 of 20 children (60 %). Areas most affected were the CS (11 children) and the COWM (9 children). Delayed myelination in COWM was found in six children (30 %), combined with gliosis in CS in three children. Twelve infants had ventricular dilatation both at 1 and 6 years of age. CONCLUSIONS: The MRI correlates of PVL, i. e. gliosis and ventricular dilatation, are common findings on cerebral MRI at 6 years of age in VLBW infants.
BACKGROUND: We have previously reported the results of cerebral MRI examinations in an unselected year cohort of very low birth weight (VLBW) infants at one year of corrected age. Twenty-one (78 %) of 27 infants had abnormal myelination, mainly in the central occipital white matter (COWM) and in the centrum semiovale (CS), seen on T2-weighted images. Twelve infants had irregular and dilated lateral ventricles. We speculated whether these findings indicated perinatal periventricular leukomalacia (PVL). Only two infants had completely normal MRI at age 1 year. OBJECTIVE: To determine whether the abnormal myelination seen at 1 year of age, was still present, either as delayed myelination or as gliosis caused by perinatal PVL. MATERIALS AND METHODS: In the present study, we report the results of follow-up cerebral MRI in 20 of these infants at 6 years of age. RESULTS: Most of the children with MRI deviations at 1 year still had abnormalities at 6 years. Abnormal myelination in the central occipital white matter combined with abnormalities in the CS or with ventricular dilatation at age 1 year, presented as gliosis in 12 of 13 children at 6 years of age. Abnormalities solely in the COWM at age 1 year had normalised in two of five children and persisted as delayed myelination in three at age 6 years. Gliotic changes in periventricular white matter were found in 12 of 20 children (60 %). Areas most affected were the CS (11 children) and the COWM (9 children). Delayed myelination in COWM was found in six children (30 %), combined with gliosis in CS in three children. Twelve infants had ventricular dilatation both at 1 and 6 years of age. CONCLUSIONS: The MRI correlates of PVL, i. e. gliosis and ventricular dilatation, are common findings on cerebral MRI at 6 years of age in VLBW infants.
Authors: K J Rademaker; C S P M Uiterwaal; F J A Beek; I C van Haastert; A F Lieftink; F Groenendaal; D E Grobbee; L S de Vries Journal: Arch Dis Child Fetal Neonatal Ed Date: 2005-06-14 Impact factor: 5.747
Authors: Tone F Bathen; Torill E Sjöbakk; Jon Skranes; Ann-Mari Brubakk; Torstein Vik; Marit Martinussen; Gunnar E Myhr; Ingrid S Gribbestad; David Axelson Journal: Pediatr Radiol Date: 2006-05-16
Authors: K A I Evensen; T Vik; J Helbostad; M S Indredavik; S Kulseng; A-M Brubakk Journal: Arch Dis Child Fetal Neonatal Ed Date: 2004-09 Impact factor: 5.747
Authors: M S Indredavik; T Vik; S Heyerdahl; S Kulseng; P Fayers; A-M Brubakk Journal: Arch Dis Child Fetal Neonatal Ed Date: 2004-09 Impact factor: 5.747
Authors: Marit Martinussen; Dana W Flanders; Bruce Fischl; Evelina Busa; Gro C Løhaugen; Jon Skranes; Torgil R Vangberg; Ann-Mari Brubakk; Olav Haraldseth; Anders M Dale Journal: J Pediatr Date: 2009-08-15 Impact factor: 4.406
Authors: Kari Anne I Evensen; Kristina Anna Djupvik Aakvik; Ingrid Marie Husby Hollund; Jon Skranes; Ann-Mari Brubakk; Marit S Indredavik Journal: Paediatr Perinat Epidemiol Date: 2022-07-22 Impact factor: 3.103