Literature DB >> 9633890

A common polymorphism in the tumour necrosis factor-alpha gene associated with high TNF levels is not a risk factor for venous thromboembolism.

K Brown1, R Luddington, T Baglin.   

Abstract

The odds ratio of homozygosity or heterozygosity for the TNF2 polymorphism in 575 patients with venous thromboembolism compared to controls was found to be 1.0 (95% CI 0.4-2.1) and 1.1 (95% CI 0.8-1.4) respectively. Comparing subgroups of patients and controls with the factor V Leiden mutation the odds ratio for the TNF2 polymorphism was 0.7 (95% CI 0.2-2.2). Despite evidence of a link between high tumour necrosis factor (TNF) levels and hypercoagulability, our results do not indicate a link between the genetic regulation of TNF production and venous thromboembolic disease.

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Year:  1998        PMID： 9633890     DOI： 10.1046/j.1365-2141.1998.00729.x

Source DB:  PubMed          Journal:  Br J Haematol        ISSN： 0007-1048            Impact factor:   6.998


  6 in total

Review 1.  Inflammation and Nutritional Science for Programs/Policies and Interpretation of Research Evidence (INSPIRE).

Authors:  Daniel J Raiten; Fayrouz A Sakr Ashour; A Catharine Ross; Simin N Meydani; Harry D Dawson; Charles B Stephensen; Bernard J Brabin; Parminder S Suchdev; Ben van Ommen
Journal:  J Nutr       Date:  2015-04-01       Impact factor: 4.798

2.  Risk of venous thromboembolism associated with single and combined effects of Factor V Leiden, Prothrombin 20210A and Methylenetethraydrofolate reductase C677T: a meta-analysis involving over 11,000 cases and 21,000 controls.

Authors:  Benedetto Simone; Valerio De Stefano; Emanuele Leoncini; Jeppe Zacho; Ida Martinelli; Joseph Emmerich; Elena Rossi; Aaron R Folsom; Wassim Y Almawi; Pierre Y Scarabin; Martin den Heijer; Mary Cushman; Silvana Penco; Amparo Vaya; Pantep Angchaisuksiri; Gulfer Okumus; Donato Gemmati; Simona Cima; Nejat Akar; Kivilcim I Oguzulgen; Véronique Ducros; Christoph Lichy; Consuelo Fernandez-Miranda; Andrzej Szczeklik; José A Nieto; Jose Domingo Torres; Véronique Le Cam-Duchez; Petar Ivanov; Carlos Cantu-Brito; Veronika M Shmeleva; Mojka Stegnar; Dotun Ogunyemi; Suhair S Eid; Nicola Nicolotti; Emma De Feo; Walter Ricciardi; Stefania Boccia
Journal:  Eur J Epidemiol       Date:  2013-07-31       Impact factor: 8.082

3.  Association of the tumor necrosis factor-alpha -308 G/A polymorphism with nasal polyposis.

Authors:  Hunkar Batikhan; Mustafa Kursat Gokcan; Esen Beder; Nejat Akar; Aysenur Ozturk; Muharrem Gerceker
Journal:  Eur Arch Otorhinolaryngol       Date:  2009-12-11       Impact factor: 2.503

4.  Correlation study of venous thromboembolism with SAA, IL-1, and TNF-a levels and gene polymorphisms in Chinese population.

Authors:  Refukaiti Abuduhalike; Juan Sun; Li Zhao; Ailiman Mahemuti
Journal:  J Thorac Dis       Date:  2019-12       Impact factor: 2.895

5.  Proinflammatory biomarkers' level and functional genetic polymorphisms in periprosthetic joint infection.

Authors:  Bülent Erdemli; Emre Anıl Özbek; Kerem Başarir; Zeynep Ceren Karahan; Duygu Öcal; Derya Biriken
Journal:  Acta Orthop Traumatol Turc       Date:  2018-01-02       Impact factor: 1.511

6.  Tumor necrosis factor alpha-308 gene polymorphism and pseudoexfoliation glaucoma.

Authors:  Oya Tekeli; M Erol Turacli; Yonca Egin; Nejat Akar; Atilla Halil Elhan
Journal:  Mol Vis       Date:  2008-09-30       Impact factor: 2.367
  6 in total

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