Literature DB >> 963345

A rapid method for the estimation of prostaglandin 15-hydroxydehydrogenase activity and its application to pharmacology.

G J Blackwell, R J Flower.   

Abstract

A novel double-isotope assay for prostaglandin 15-hydroxydehydrogenase (PGDH) is described. 2 The assay is simple, rapid, precise, completely specific for PGDH, and free from artefacts. The results obtained correlate well with a conventional assay. 3 The method is versatile, being applicable to estimations of enzyme activity in cell-free systems as well as perfused organs, and is well suited to the assay of PGDH inhibitors.

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Year:  1976        PMID： 963345      PMCID： PMC1667038          DOI： 10.1111/j.1476-5381.1976.tb10389.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  17 in total

1.  Anti-fertility drugs; novel non-hormonal compounds that inhibit prostaglandin metabolism.

Authors:  L J Lerner; G Galliani; P Carminati; M C Mosca
Journal:  Nature       Date:  1975-07-10       Impact factor: 49.962

2.  PROSTAGLANDINS AND RELATED FACTORS. 28. METABOLISM OF PROSTAGLANDIN E1 IN GUINEA PIG LUNG: THE STRUCTURES OF TWO METABOLITES.

Authors:  B SAMUELSSON
Journal:  J Biol Chem       Date:  1964-12       Impact factor: 5.157

3.  Proceedings: Effects of steriod hormones on tissue levels of prostaglandin 15-hydroxydehydrogenase in the rat.

Authors:  G J Blackwell; R J Flower
Journal:  Br J Pharmacol       Date:  1976-03       Impact factor: 8.739

4.  Prostaglandin 15-hydroxy dehydrogenase and delta13 reductase levels in the lungs of maternal, fetal and neonatal rabbits.

Authors:  F F Sun; S B Armour
Journal:  Prostaglandins       Date:  1974-08-25

5.  Release of additional factors in anaphylaxis and its antagonism by anti-inflammatory drugs.

Authors:  P J Piper; J R Vane
Journal:  Nature       Date:  1969-07-05       Impact factor: 49.962

6.  Metabolic degradation of prostaglandin E1 in the lung and kidney of rats in endotoxin shock.

Authors:  J Nakano; A V Prancan
Journal:  Proc Soc Exp Biol Med       Date:  1973-11

7.  Carnitine-dependent oxidation of prostaglandins.

Authors:  M Johnson; P Davison; P W Ramwell
Journal:  J Biol Chem       Date:  1972-09-10       Impact factor: 5.157

8.  On the metabolism of prostaglandins E 1 and E 2 in the guinea pig.

Authors:  M Hamberg; B Samuelsson
Journal:  J Biol Chem       Date:  1972-06-10       Impact factor: 5.157

9.  Prostaglandin inactivation in guinea-pig lung and its inhibition.

Authors:  D J Crutchley; P J Piper
Journal:  Br J Pharmacol       Date:  1974-10       Impact factor: 8.739

10.  Rapid reduction of prostaglandin 15-hydroxy dehydrogenase activity in rat tissues after treatment with protein synthesis inhibitors.

Authors:  G J Blackwell; R J Flower; J R Vane
Journal:  Br J Pharmacol       Date:  1975-10       Impact factor: 8.739
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