Literature DB >> 9632628

In vitro resistance to thrombin-induced platelet microbicidal protein is associated with enhanced progression and hematogenous dissemination in experimental Staphylococcus aureus infective endocarditis.

V K Dhawan1, A S Bayer, M R Yeaman.   

Abstract

We examined the influence of thrombin-induced platelet microbicidal protein 1 (tPMP-1) on the progression and hematogenous dissemination of experimental endocarditis caused by isogenic Staphylococcus aureus strains differing in tPMP susceptibility (tPMPs) or resistance (tPMPr) in vitro. Following simultaneous challenge of animals with both strains, significantly higher tPMPr bacterial densities were present in vegetations (P < 0.0001), kidneys (P < 0. 0001), and spleens (P < 0.0001) compared with those for the tPMPs strain. These data indicate that tPMP-1 limits the intravegetation proliferation and hematogenous dissemination of a tPMPs strain in experimental endocarditis, while the tPMPr phenotype confers a selective advantage associated with the enhanced progression of this infection.

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Year:  1998        PMID： 9632628      PMCID： PMC108375     

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  23 in total

1.  Effects of interleukin-1, lipopolysaccharide, and streptococci on procoagulant activity of cultured human cardiac valve endothelial and stromal cells.

Authors:  T A Drake; M Pang
Journal:  Infect Immun       Date:  1989-02       Impact factor: 3.441

2.  Phenotypic characterization of Streptococcus sanguis virulence factors associated with bacterial endocarditis.

Authors:  M C Herzberg; K Gong; G D MacFarlane; P R Erickson; A H Soberay; P H Krebsbach; G Manjula; K Schilling; W H Bowen
Journal:  Infect Immun       Date:  1990-02       Impact factor: 3.441

3.  Platelet microbicidal protein alone and in combination with antibiotics reduces Staphylococcus aureus adherence to platelets in vitro.

Authors:  M R Yeaman; P M Sullam; P F Dazin; A S Bayer
Journal:  Infect Immun       Date:  1994-08       Impact factor: 3.441

4.  In vitro resistance to platelet microbicidal protein correlates with endocarditis source among bacteremic staphylococcal and streptococcal isolates.

Authors:  T Wu; M R Yeaman; A S Bayer
Journal:  Antimicrob Agents Chemother       Date:  1994-04       Impact factor: 5.191

5.  Partial characterization and staphylocidal activity of thrombin-induced platelet microbicidal protein.

Authors:  M R Yeaman; S M Puentes; D C Norman; A S Bayer
Journal:  Infect Immun       Date:  1992-03       Impact factor: 3.441

6.  Role of the sar locus of Staphylococcus aureus in induction of endocarditis in rabbits.

Authors:  A L Cheung; M R Yeaman; P M Sullam; M D Witt; A S Bayer
Journal:  Infect Immun       Date:  1994-05       Impact factor: 3.441

7.  Thrombin-induced rabbit platelet microbicidal protein is fungicidal in vitro.

Authors:  M R Yeaman; A S Ibrahim; J E Edwards; A S Bayer; M A Ghannoum
Journal:  Antimicrob Agents Chemother       Date:  1993-03       Impact factor: 5.191

8.  The platelet interactivity phenotype of Streptococcus sanguis influences the course of experimental endocarditis.

Authors:  M C Herzberg; G D MacFarlane; K Gong; N N Armstrong; A R Witt; P R Erickson; M W Meyer
Journal:  Infect Immun       Date:  1992-11       Impact factor: 3.441

9.  Effect of thrombocytopenia on the early course of streptococcal endocarditis.

Authors:  P M Sullam; U Frank; M R Yeaman; M G Täuber; A S Bayer; H F Chambers
Journal:  J Infect Dis       Date:  1993-10       Impact factor: 5.226

10.  Platelet microbicidal protein enhances antibiotic-induced killing of and postantibiotic effect in Staphylococcus aureus.

Authors:  M R Yeaman; D C Norman; A S Bayer
Journal:  Antimicrob Agents Chemother       Date:  1992-08       Impact factor: 5.191
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  24 in total

1.  Thrombin-induced platelet microbicidal protein susceptibility phenotype influences the outcome of oxacillin prophylaxis and therapy of experimental Staphylococcus aureus endocarditis.

Authors:  V K Dhawan; A S Bayer; M R Yeaman
Journal:  Antimicrob Agents Chemother       Date:  2000-11       Impact factor: 5.191

2.  Staphylococcus aureus, Platelets, and the Heart.

Authors: 
Journal:  Curr Infect Dis Rep       Date:  2000-08       Impact factor: 3.725

3.  DltABCD- and MprF-mediated cell envelope modifications of Staphylococcus aureus confer resistance to platelet microbicidal proteins and contribute to virulence in a rabbit endocarditis model.

Authors:  Christopher Weidenmaier; Andreas Peschel; Volkhard A J Kempf; Natalie Lucindo; Michael R Yeaman; Arnold S Bayer
Journal:  Infect Immun       Date:  2005-12       Impact factor: 3.441

4.  In vitro cross-resistance to daptomycin and host defense cationic antimicrobial peptides in clinical methicillin-resistant Staphylococcus aureus isolates.

Authors:  Nagendra N Mishra; James McKinnell; Michael R Yeaman; Aileen Rubio; Cynthia C Nast; Liang Chen; Barry N Kreiswirth; Arnold S Bayer
Journal:  Antimicrob Agents Chemother       Date:  2011-06-27       Impact factor: 5.191

Review 5.  Bacterial resistance mechanisms against host defense peptides.

Authors:  Tomaz Koprivnjak; Andreas Peschel
Journal:  Cell Mol Life Sci       Date:  2011-05-11       Impact factor: 9.261

6.  Low-level resistance of Staphylococcus aureus to thrombin-induced platelet microbicidal protein 1 in vitro associated with qacA gene carriage is independent of multidrug efflux pump activity.

Authors:  A S Bayer; L I Kupferwasser; M H Brown; R A Skurray; S Grkovic; T Jones; K Mukhopadhay; M R Yeaman
Journal:  Antimicrob Agents Chemother       Date:  2006-07       Impact factor: 5.191

7.  Plasmid-mediated resistance to thrombin-induced platelet microbicidal protein in staphylococci: role of the qacA locus.

Authors:  L I Kupferwasser; R A Skurray; M H Brown; N Firth; M R Yeaman; A S Bayer
Journal:  Antimicrob Agents Chemother       Date:  1999-10       Impact factor: 5.191

8.  Factors influencing time to vancomycin-induced clearance of nonendocarditis methicillin-resistant Staphylococcus aureus bacteremia: role of platelet microbicidal protein killing and agr genotypes.

Authors:  Pamela A Moise; Alan Forrest; Arnold S Bayer; Yan Q Xiong; Michael R Yeaman; George Sakoulas
Journal:  J Infect Dis       Date:  2010-01-15       Impact factor: 5.226

9.  Platelets and Platelet Inhibitors in Infective Endocarditis.

Authors:  Bruno Hoen
Journal:  Curr Infect Dis Rep       Date:  2002-08       Impact factor: 3.725

10.  In vitro resistance to thrombin-induced platelet microbicidal protein among clinical bacteremic isolates of Staphylococcus aureus correlates with an endovascular infectious source.

Authors:  A S Bayer; D Cheng; M R Yeaman; G R Corey; R S McClelland; L J Harrel; V G Fowler
Journal:  Antimicrob Agents Chemother       Date:  1998-12       Impact factor: 5.191
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