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Literature DB >> 963210

Activation-inactivation coupling in Myxicola giant axons injected with tetraethylammonium.

Abstract

Myxicola giant axons internally injected with tetraethylammonium chloride to block potassium currents were examined under voltage clamp. The sodium inactivation time constants obtained from the decline in INa during step depolarizations were substantially smaller than those obtained using conditioning prepulses to the same potentials and the ratios agreed with previous observations using TTX. Inactivation shifts were also measured and found to be comparable to previous results.

Entities: Chemical

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Year: 1976 PMID： 963210 PMCID： PMC1334939 DOI： 10.1016/S0006-3495(76)85749-9

Source DB: PubMed Journal: Biophys J ISSN： 0006-3495 Impact factor: 4.033

12 in total

1. Ionic current measurements in the squid giant axon membrane.

Authors: K S COLE; J W MOORE
Journal: J Gen Physiol Date: 1960-09 Impact factor: 4.086

2. A quantitative description of membrane current and its application to conduction and excitation in nerve.

Authors: A L HODGKIN; A F HUXLEY
Journal: J Physiol Date: 1952-08 Impact factor: 5.182

3. Comparison of two-pulse sodium inactivation with reactivation in Myxicola giant axons.

Authors: C L Schauf
Journal: Biophys J Date: 1976-03 Impact factor: 4.033

4. Aminopyridines and sparteine as inhibitors of membrane potassium conductance: effects on Myxicola giant axons and the lobster neuromuscular junction.

Authors: C L Schauf; C A Colton; J S Colton; F A Davis
Journal: J Pharmacol Exp Ther Date: 1976-05 Impact factor: 4.030

8. Selective modification of sodium channel gating in lobster axons by 2, 4, 6-trinitrophenol: Evidence for two inactivation mechanisms.

Authors: G S Oxford; J P Pooler
Journal: J Gen Physiol Date: 1975-12 Impact factor: 4.086

3. Solvent substitution as a probe of channel gating in Myxicola. Differential effects of D2O on some components of membrane conductance.

Authors: C L Schauf; J O Bullock
Journal: Biophys J Date: 1980-05 Impact factor: 4.033

10. Solvent substitution as a probe of channel gating in Myxicola. Effects of D2O on kinetic properties of drugs that occlude channels.

Authors: C L Schauf; J O Bullock
Journal: Biophys J Date: 1982-02 Impact factor: 4.033

Activation-inactivation coupling in Myxicola giant axons injected with tetraethylammonium.

1. Ionic current measurements in the squid giant axon membrane.

2. A quantitative description of membrane current and its application to conduction and excitation in nerve.

3. Comparison of two-pulse sodium inactivation with reactivation in Myxicola giant axons.

4. Aminopyridines and sparteine as inhibitors of membrane potassium conductance: effects on Myxicola giant axons and the lobster neuromuscular junction.

5. Sodium currents in Myxicola axons. Nonexponential recovery from the inactive state.

6. The effect of changing the internal solution on sodium inactivation and related phenomena in giant axons.

7. Inactivation of the sodium current in Myxicola giant axons. Evidence for coupling to the activation process.

8. Selective modification of sodium channel gating in lobster axons by 2, 4, 6-trinitrophenol: Evidence for two inactivation mechanisms.

9. ANOMALOUS RECTIFICATION IN THE SQUID GIANT AXON INJECTED WITH TETRAETHYLAMMONIUM CHLORIDE.

10. Quantitative description of sodium and potassium currents and computed action potentials in Myxicola giant axons.

1. Inactivation of sodium channels: second order kinetics in myelinated nerve.

2. Tetraethylammonium blockade of calcium-activated potassium channels in clonal anterior pituitary cells.

3. Solvent substitution as a probe of channel gating in Myxicola. Differential effects of D2O on some components of membrane conductance.

4. Sodium channel inactivation in the crayfish giant axon. Must channels open before inactivating?

5. Experimental evidence consistent with aggregation kinetics in the sodium current of Myxicola giant axons.

6. Combined voltage-clamp and dialysis of Myxicola axons: behaviour of membrane asymmetry currents.

7. Internal cesium alters sodium inactivation in Myxicola.

8. Inhibition of potassium conductance with external tetraethylammonium ion in Myxicola giant axons.

9. Gallamine triethiodide-induced modifications of sodium conductance in Myxicola giant axons.

10. Solvent substitution as a probe of channel gating in Myxicola. Effects of D2O on kinetic properties of drugs that occlude channels.