K A Holmkvist1, R K Roenigk. 1. Department of Dermatology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA.
Abstract
BACKGROUND: Mohs micrographic surgery (MMS) is believed to be a highly effective treatment of squamous cell carcinoma (SCC) of the lip. OBJECTIVE: The goals of our study were to determine the long-term (5-year) outcome of patients treated with MMS for SCC of the lip and to identify factors associated with tumor recurrence. METHODS: Clinical and histopathologic data from 50 consecutive cases of SCC of the lip treated with MMS were retrospectively reviewed. RESULTS: There were no tumor-related deaths or metastases. Forty-six patients (92%) remained free of disease. Four patients (8%) were diagnosed with SCC at the surgical site after MMS. Recurrent lesions tended to be superficial and occurred in the setting of severe actinic cheilitis. The average time to diagnosis after MMS was 2.5 years. All patients with recurrent disease were treated with further MMS and had successful results. No recurrences were seen among patients who received adjuvant treatment for actinic cheilitis with the carbon dioxide (CO2) laser, had clinical lesions 1 cm or less in diameter, or had post-MMS defects 2 cm or less in diameter. CONCLUSION: MMS is highly effective for treating both primary and recurrent SCC of the lip. Treatment of coexisting actinic cheilitis may lower the risk for local recurrence after MMS.
BACKGROUND: Mohs micrographic surgery (MMS) is believed to be a highly effective treatment of squamous cell carcinoma (SCC) of the lip. OBJECTIVE: The goals of our study were to determine the long-term (5-year) outcome of patients treated with MMS for SCC of the lip and to identify factors associated with tumor recurrence. METHODS: Clinical and histopathologic data from 50 consecutive cases of SCC of the lip treated with MMS were retrospectively reviewed. RESULTS: There were no tumor-related deaths or metastases. Forty-six patients (92%) remained free of disease. Four patients (8%) were diagnosed with SCC at the surgical site after MMS. Recurrent lesions tended to be superficial and occurred in the setting of severe actinic cheilitis. The average time to diagnosis after MMS was 2.5 years. All patients with recurrent disease were treated with further MMS and had successful results. No recurrences were seen among patients who received adjuvant treatment for actinic cheilitis with the carbon dioxide (CO2) laser, had clinical lesions 1 cm or less in diameter, or had post-MMS defects 2 cm or less in diameter. CONCLUSION: MMS is highly effective for treating both primary and recurrent SCC of the lip. Treatment of coexisting actinic cheilitis may lower the risk for local recurrence after MMS.
Authors: Alejandra Tomás-Velázquez; Onofre Sanmartin-Jiménez; Joan R Garcés; Manuel A Rodríguez-Prieto; Verónica Ruiz-Salas; Esther De Eusebio-Murillo; Román Miñano-Medrano; Begoña Escutia-Muñoz; Ángeles Flórez-Menéndez; Juan L Artola-Igarza; Alberto Alfaro-Rubio; Pilar Gil; Yolanda Delgado-Jiménez; Julia M Sanchez-Schmidt; Irati Allende-Markixana; María L Alonso-Pacheco; Beatriz García-Bracamonte; Pablo De la Cueva-Dobao; Raquel Navarro-Tejedor; Cristina Ciudad-Blanco; Lucía Carnero-González; Hugo Vázquez-Veiga; Natividad Cano-Martínez; Eva Vilarrasa-Rull; Pedro Sanchez-Sambucety; José L López-Estebaranz; Rafael Botella-Estrada; Beatriz Gonzalez-Sixto; Antonio Martorell-Calatayud; Victoriano Morales-Gordillo; Agustí Toll-Abelló; Izascun Ocerin-Guerra; Matías Mayor-Arenal; Ricardo Suárez-Fernández; Laura Sainz-Gaspar; Miguel A Descalzo; Ignacio García-Doval; Pedro Redondo Journal: Acta Derm Venereol Date: 2021-11-24 Impact factor: 3.875
Authors: Selma Schuartz Cernea; Gabriel Gontijo; Eugenio Raul de Almeida Pimentel; Roberto Gomes Tarlé; Glaysson Tassara; Juliana Areas de Souza Lima Beltrame Ferreira; Victor Miguel Coutinho Fernandes; Wanderley Marques Bernardo Journal: An Bras Dermatol Date: 2016 Sep-Oct Impact factor: 1.896