Literature DB >> 9630864

Synthesis and anti-tubulin activity of ustiloxin D derivatives.

N Morisaki1, Y Mitsui, Y Yamashita, Y Koiso, R Shirai, Y Hashimoto, S Iwasaki.   

Abstract

Ustiloxin D, produced by the rice plant pathogen Ustilaginoidea virens, exhibits potent anti-tubulin activity. In order to elucidate the effects of functional groups in ustiloxin D on its activity, several derivatives were synthesized and their anti-tubulin activities were estimated. The N,N-dimethylamino derivative and the 14-O-methyl derivative were inactive (IC50 > 50 microM). 20-Hydroxymethylated ustiloxin D showed decreased inhibitory activity compared with ustiloxin D.

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Year:  1998        PMID： 9630864     DOI： 10.7164/antibiotics.51.423

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  6 in total

1.  The enantioselective synthesis of phomopsin B.

Authors:  Joshua S Grimley; Andrew M Sawayama; Hiroko Tanaka; Michelle M Stohlmeyer; Thomas F Woiwode; Thomas J Wandless
Journal:  Angew Chem Int Ed Engl       Date:  2007       Impact factor: 15.336

2.  Evolution of the total syntheses of ustiloxin natural products and their analogues.

Authors:  Pixu Li; Cory D Evans; Yongzhong Wu; Bin Cao; Ernest Hamel; Madeleine M Joullié
Journal:  J Am Chem Soc       Date:  2008-01-30       Impact factor: 15.419

3.  Main Ustilaginoidins and Their Distribution in Rice False Smut Balls.

Authors:  Jiajia Meng; Weibo Sun; Ziling Mao; Dan Xu; Xiaohan Wang; Shiqiong Lu; Daowan Lai; Yang Liu; Ligang Zhou; Guozhen Zhang
Journal:  Toxins (Basel)       Date:  2015-10-09       Impact factor: 4.546

4.  The Contents of Ustiloxins A and B along with Their Distribution in Rice False Smut Balls.

Authors:  Xiaohan Wang; Xiaoxiang Fu; Fengke Lin; Weibo Sun; Jiajia Meng; Ali Wang; Daowan Lai; Ligang Zhou; Yang Liu
Journal:  Toxins (Basel)       Date:  2016-09-06       Impact factor: 4.546

5.  Development of Colloidal Gold-Based Lateral Flow Immunoassay for Rapid Qualitative and SemiQuantitative Analysis of Ustiloxins A and B in Rice Samples.

Authors:  Xiaoxiang Fu; Rushan Xie; Jian Wang; Xiaojiao Chen; Xiaohan Wang; Weibo Sun; Jiajia Meng; Daowan Lai; Ligang Zhou; Baomin Wang
Journal:  Toxins (Basel)       Date:  2017-02-24       Impact factor: 4.546

6.  Development of a Monoclonal Antibody-Based icELISA for the Detection of Ustiloxin B in Rice False Smut Balls and Rice Grains.

Authors:  Xiaoxiang Fu; Ali Wang; Xiaohan Wang; Fengke Lin; Lishan He; Daowan Lai; Yang Liu; Qing X Li; Ligang Zhou; Baoming Wang
Journal:  Toxins (Basel)       Date:  2015-08-28       Impact factor: 4.546
  6 in total

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