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Literature DB >> 9630247

Autoantigenic properties of some protein subunits of catalytically active complexes of human ribonuclease P.

N Jarrous¹, P S Eder, C Guerrier-Takada, C Hoog, S Altman.

Abstract

At least six proteins co-purify with human ribonuclease P (RNase P), a tRNA processing ribonucleoprotein. Two of these proteins, Rpp30 and Rpp38, are Th autoantigens. Recombinant Rpp30 and Rpp38 are also recognized by Th sera from systemic sclerosis patients. Two of the other proteins associated with RNase P, Rpp20 and Rpp40, do not cross-react with Th sera. Polyclonal antibodies raised against all four recombinant proteins recognize the corresponding proteins associated with RNase P and precipitate active holoenzyme. Catalytically active RNase P holoenzyme can be separated from the nucleolar and mitochondrial RNA processing endoribonuclease, RNase MRP, even though these two enzymes may share some subunits.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1998 PMID： 9630247 PMCID： PMC1369627

Source DB: PubMed Journal: RNA ISSN： 1355-8382 Impact factor: 4.942

33 in total

1. Analysis of the expression of a large number of novel genes isolated from mouse prepubertal testis.

Authors: M Starborg; E Brundell; C Höög
Journal: Mol Reprod Dev Date: 1992-11 Impact factor: 2.609

2. Basic local alignment search tool.

Authors: S F Altschul; W Gish; W Miller; E W Myers; D J Lipman
Journal: J Mol Biol Date: 1990-10-05 Impact factor: 5.469

3. Similar cage-shaped structures for the RNA components of all ribonuclease P and ribonuclease MRP enzymes.

Authors: A C Forster; S Altman
Journal: Cell Date: 1990-08-10 Impact factor: 41.582

4. Two interdependent basic domains in nucleoplasmin nuclear targeting sequence: identification of a class of bipartite nuclear targeting sequence.

Authors: J Robbins; S M Dilworth; R A Laskey; C Dingwall
Journal: Cell Date: 1991-02-08 Impact factor: 41.582

5. The RNA moiety of ribonuclease P is the catalytic subunit of the enzyme.

Authors: C Guerrier-Takada; K Gardiner; T Marsh; N Pace; S Altman
Journal: Cell Date: 1983-12 Impact factor: 41.582

6. The RNA processing enzyme RNase MRP is identical to the Th RNP and related to RNase P.

Authors: H A Gold; J N Topper; D A Clayton; J Craft
Journal: Science Date: 1989-09-22 Impact factor: 47.728

7. Identification and characterization of an RNA molecule that copurifies with RNase P activity from HeLa cells.

Authors: M Bartkiewicz; H Gold; S Altman
Journal: Genes Dev Date: 1989-04 Impact factor: 11.361

8. Characterization of human MRP/Th RNA and its nuclear gene: full length MRP/Th RNA is an active endoribonuclease when assembled as an RNP.

Authors: J N Topper; D A Clayton
Journal: Nucleic Acids Res Date: 1990-02-25 Impact factor: 16.971

9. Immunolocalization of 7-2-ribonucleoprotein in the granular component of the nucleolus.

Authors: G Reimer; I Raska; U Scheer; E M Tan
Journal: Exp Cell Res Date: 1988-05 Impact factor: 3.905

10. Antibodies in human serum that precipitate ribonuclease P.

Authors: H A Gold; J Craft; J A Hardin; M Bartkiewicz; S Altman
Journal: Proc Natl Acad Sci U S A Date: 1988-08 Impact factor: 11.205

32 in total

1. The RNase P associated with HeLa cell mitochondria contains an essential RNA component identical in sequence to that of the nuclear RNase P.

Authors: R S Puranam; G Attardi
Journal: Mol Cell Biol Date: 2001-01 Impact factor: 4.272

10. Partial reconstitution of human RNase P in HeLa cells between its RNA subunit with an affinity tag and the intact protein components.

Authors: Yong Li; Sidney Altman
Journal: Nucleic Acids Res Date: 2002-09-01 Impact factor: 16.971

Autoantigenic properties of some protein subunits of catalytically active complexes of human ribonuclease P.

1. Analysis of the expression of a large number of novel genes isolated from mouse prepubertal testis.

2. Basic local alignment search tool.

3. Similar cage-shaped structures for the RNA components of all ribonuclease P and ribonuclease MRP enzymes.

4. Two interdependent basic domains in nucleoplasmin nuclear targeting sequence: identification of a class of bipartite nuclear targeting sequence.

5. The RNA moiety of ribonuclease P is the catalytic subunit of the enzyme.

6. The RNA processing enzyme RNase MRP is identical to the Th RNP and related to RNase P.

7. Identification and characterization of an RNA molecule that copurifies with RNase P activity from HeLa cells.

8. Characterization of human MRP/Th RNA and its nuclear gene: full length MRP/Th RNA is an active endoribonuclease when assembled as an RNP.

9. Immunolocalization of 7-2-ribonucleoprotein in the granular component of the nucleolus.

10. Antibodies in human serum that precipitate ribonuclease P.

1. The RNase P associated with HeLa cell mitochondria contains an essential RNA component identical in sequence to that of the nuclear RNase P.

Review 2. Eukaryotic ribonuclease P: increased complexity to cope with the nuclear pre-tRNA pathway.

3. Varieties of RNase P: a nomenclature problem?

4. RNA-protein interactions in the human RNase MRP ribonucleoprotein complex.

5. Protein-RNA interactions in the subunits of human nuclear RNase P.

6. A protein subunit of human RNase P, Rpp14, and its interacting partner, OIP2, have 3'-->5' exoribonuclease activity.

7. Function and subnuclear distribution of Rpp21, a protein subunit of the human ribonucleoprotein ribonuclease P.

8. An active precursor in assembly of yeast nuclear ribonuclease P.

9. Alterations in the intracellular level of a protein subunit of human RNase P affect processing of tRNA precursors.

10. Partial reconstitution of human RNase P in HeLa cells between its RNA subunit with an affinity tag and the intact protein components.