Literature DB >> 9629051

[Changes in crystallinity by sterilization and processing of ultrahigh molecular polyethylene used in endoprosthetics].

S Fuchs1, T Schmidt, S Haftka, J Jerosch.   

Abstract

PURPOSE OF THE STUDY: We wanted to analyze crystallinity changes during sterilization in raw and in UHMWPE components for total joint arthroplasty manufactured.
MATERIALS AND METHODS: To analyze the crystallinity DSC measurements and to determine the relative crystallinity infrared spectroscopy was performed. The DSC measurements were based on a comparison between the melting enthalpy of one known material to the unknown material.
RESULTS: The raw manufactured non-sterilized sample showed a value for the DSC-measured crystallinity of 55.5%; the sample after gamma-sterilization without air was 56.0%, and with air 56.5%. The crystallinity after ethylene-oxide sterilization was 57.7% and after autoclavation 57.9%. The manufacturing time from the raw to the arthroplasty part showed some what different results. The average crystallinity of the samples differed between 55.4% and 61.6%. The best results were achieved in ETO-sterilized samples and one gamma-sterilized sample without air. The highest values were seen for the Hylamer.
CONCLUSION: In summary, the best values for crystallinity were seen in both raw and completed arthroplasty products with ETO sterilization. For medical use cancerogenous factors must be excluded. Gamma-sterilization without air can be accepted as well. Increasing the crystallinity too much can lead to more wear debris.

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Year:  1998        PMID: 9629051     DOI: 10.1007/s001130050284

Source DB:  PubMed          Journal:  Unfallchirurg        ISSN: 0177-5537            Impact factor:   1.000


  2 in total

1.  Comparative evaluation of the degree of indomethacin crystallinity by chemoinfometrical Fourier-transformed [corrected] near-infrared spectroscopy and conventional powder X-ray diffractometry.

Authors:  M Otsuka; F Kato; Y Matsuda
Journal:  AAPS PharmSci       Date:  2000

2.  Evaluation of the microcrystallinity of a drug substance, indomethacin, in a pharmaceutical model tablet by chemometric FT-Raman spectroscopy.

Authors:  Takehiro Okumura; Makoto Otsuka
Journal:  Pharm Res       Date:  2005-08-03       Impact factor: 4.200

  2 in total

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