BACKGROUND: We tested the hypothesis that a functional biallelic repetitive element in the 5' regulatory region of the human serotonin transporter gene (SLC6A4) confers susceptibility to serotonin-related personality traits underlying alcohol dependence with dissocial behavior. METHODS: The association study was focused on 64 alcohol-dependent subjects with a dissocial personality disorder (according to ICD-10) who were derived from 315 German alcohol-dependent subjects. The Tridimensional Personality Questionnaire (TPQ) was applied to assess personality dimensions in 101 alcohol-dependent men, including 39 dissocial alcoholics. RESULTS: Our association analyses revealed a trend towards a higher frequency of the short (S) allele of the SLC6A4 polymorphism in dissocial alcoholics compared to 216 German controls (chi 2 = 2.81, df = 1, p = 0.094). Dissocial alcoholics carrying the S/S genotype exhibited significant lower scores of harm avoidance compared to those lacking it (U-test, p = 0.015). Significantly higher novelty seeking scores were obtained in dissocial alcoholics carrying the S allele relative to those lacking it (U-test, p = 0.021). CONCLUSIONS: Our tentative association findings in dissocial alcoholics suggest that the S allele of the 5' regulatory SLC6A4 polymorphism confers susceptibility to a temperamental profile of high novelty seeking and low harm avoidance that has been postulated to underlie dissocial (type-2) alcoholism according to Cloninger's neurogenetic theory of personality.
RCT Entities:
BACKGROUND: We tested the hypothesis that a functional biallelic repetitive element in the 5' regulatory region of the humanserotonin transporter gene (SLC6A4) confers susceptibility to serotonin-related personality traits underlying alcohol dependence with dissocial behavior. METHODS: The association study was focused on 64 alcohol-dependent subjects with a dissocial personality disorder (according to ICD-10) who were derived from 315 German alcohol-dependent subjects. The Tridimensional Personality Questionnaire (TPQ) was applied to assess personality dimensions in 101 alcohol-dependent men, including 39 dissocial alcoholics. RESULTS: Our association analyses revealed a trend towards a higher frequency of the short (S) allele of the SLC6A4 polymorphism in dissocial alcoholics compared to 216 German controls (chi 2 = 2.81, df = 1, p = 0.094). Dissocial alcoholics carrying the S/S genotype exhibited significant lower scores of harm avoidance compared to those lacking it (U-test, p = 0.015). Significantly higher novelty seeking scores were obtained in dissocial alcoholics carrying the S allele relative to those lacking it (U-test, p = 0.021). CONCLUSIONS: Our tentative association findings in dissocial alcoholics suggest that the S allele of the 5' regulatory SLC6A4 polymorphism confers susceptibility to a temperamental profile of high novelty seeking and low harm avoidance that has been postulated to underlie dissocial (type-2) alcoholism according to Cloninger's neurogenetic theory of personality.
Authors: Howard Steiger; Jodie Richardson; Ridha Joober; Lise Gauvin; Mimi Israel; Kenneth R Bruce; N M K Ng Ying Kin; Heidi Howard; Simon N Young Journal: J Psychiatry Neurosci Date: 2007-09 Impact factor: 6.186
Authors: Lars Oreland; Gianvito Lagravinese; Simone Toffoletto; Kent W Nilsson; Jaanus Harro; C Robert Cloninger; Erika Comasco Journal: J Neural Transm (Vienna) Date: 2017-01-04 Impact factor: 3.575
Authors: G Gerra; L Garofano; L Castaldini; F Rovetto; A Zaimovic; G Moi; M Bussandri; B Branchi; F Brambilla; G Friso; C Donnini Journal: J Neural Transm (Vienna) Date: 2005-01-24 Impact factor: 3.575
Authors: Kristen C Jacobson; Cheryl L Beseler; Jessica Lasky-Su; Stephen V Faraone; Stephen J Glatt; William S Kremen; Michael J Lyons; Ming T Tsuang Journal: Am J Med Genet B Neuropsychiatr Genet Date: 2008-10-05 Impact factor: 3.568
Authors: R Kathryn McHugh; Stefan G Hofmann; Anu Asnaani; Alice T Sawyer; Michael W Otto Journal: Drug Alcohol Depend Date: 2010-01-08 Impact factor: 4.492