OBJECTIVE: To determine why patients with Huntington disease are apparently unaware of their involuntary movements. DESIGN: Correlative study using a subjective report questionnaire of physical symptoms and objective measures of neurologic and cognitive dysfunction. PATIENTS: Forty patients with Huntington disease attending a regional Huntington disease clinic. RESULTS: Patients were poor at reporting experiential symptoms of involuntary movements. There was no relationship between self-report of these symptoms and objective indices of motor dysfunction or severity of cognitive impairment. Patients could, however, report secondary consequences of their movement disorder, which correlated highly with nonchoreic indices of motor dysfunction. CONCLUSIONS: Patients with Huntington disease have impaired subjective experience of chorea. Denial of symptoms is likely to have a physiological basis and is not a secondary consequence of patients' cognitive impairment or a psychological defense against a debilitating disease.
OBJECTIVE: To determine why patients with Huntington disease are apparently unaware of their involuntary movements. DESIGN: Correlative study using a subjective report questionnaire of physical symptoms and objective measures of neurologic and cognitive dysfunction. PATIENTS: Forty patients with Huntington disease attending a regional Huntington disease clinic. RESULTS:Patients were poor at reporting experiential symptoms of involuntary movements. There was no relationship between self-report of these symptoms and objective indices of motor dysfunction or severity of cognitive impairment. Patients could, however, report secondary consequences of their movement disorder, which correlated highly with nonchoreic indices of motor dysfunction. CONCLUSIONS:Patients with Huntington disease have impaired subjective experience of chorea. Denial of symptoms is likely to have a physiological basis and is not a secondary consequence of patients' cognitive impairment or a psychological defense against a debilitating disease.
Authors: Kevin Duff; Jane S Paulsen; Leigh J Beglinger; Douglas R Langbehn; Chiachi Wang; Julie C Stout; Christopher A Ross; Elizabeth Aylward; Noelle E Carlozzi; Sarah Queller Journal: J Neuropsychiatry Clin Neurosci Date: 2010 Impact factor: 2.198
Authors: Camille L Julien; Jennifer C Thompson; Sue Wild; Pamela Yardumian; Julie S Snowden; Gwen Turner; David Craufurd Journal: J Neurol Neurosurg Psychiatry Date: 2006-12-18 Impact factor: 10.154
Authors: Noelle E Carlozzi; Nicholas R Boileau; Joel S Perlmutter; Kelvin L Chou; Julie C Stout; Jane S Paulsen; Michael K McCormack; David Cella; Martha A Nance; Jin-Shei Lai; Praveen Dayalu Journal: J Neurol Date: 2018-04-23 Impact factor: 4.849
Authors: Jürgen E Andrich; Michael Wobben; Peter Klotz; Oliver Goetze; Carsten Saft Journal: J Neural Transm (Vienna) Date: 2009-09-22 Impact factor: 3.575
Authors: Elizabeth A McCusker; David G Gunn; Eric A Epping; Clement T Loy; Kylie Radford; Jane Griffith; James A Mills; Jeffrey D Long; Jane S Paulsen Journal: Neurology Date: 2013-08-21 Impact factor: 9.910