Literature DB >> 9626754

Effects of bile acids on hepatocellular signaling and secretion.

U Beuers1.   

Abstract

Bile acids modulate hepatocellular signaling pathways in vitro at physiological concentrations. The present paper provides a brief overview of the effects of bile acids on three key messengers in liver cells: cytosolic free calcium, protein kinase A and protein kinase C.

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Year:  1997        PMID： 9626754      PMCID： PMC2589332     

Source DB:  PubMed          Journal:  Yale J Biol Med        ISSN： 0044-0086


  34 in total

1.  Hepatocellular protein kinase C activation by bile acids: implications for regulation of cholesterol 7 alpha-hydroxylase.

Authors:  R T Stravitz; Y P Rao; Z R Vlahcevic; E C Gurley; W D Jarvis; P B Hylemon
Journal:  Am J Physiol       Date:  1996-08

2.  Ursodeoxycholic acid therapy in pediatric patients with progressive familial intrahepatic cholestasis.

Authors:  E Jacquemin; D Hermans; A Myara; D Habes; D Debray; M Hadchouel; E M Sokal; O Bernard
Journal:  Hepatology       Date:  1997-03       Impact factor: 17.425

3.  Effect of ursodeoxycholic acid on liver and bile duct disease in primary sclerosing cholangitis. A 3-year pilot study with a placebo-controlled study period.

Authors:  A Stiehl; S Walker; L Stiehl; G Rudolph; W J Hofmann; L Theilmann
Journal:  J Hepatol       Date:  1994-01       Impact factor: 25.083

4.  Regulation of activity and apical targeting of the Cl-/HCO3- exchanger in rat hepatocytes.

Authors:  A Benedetti; M Strazzabosco; O C Ng; J L Boyer
Journal:  Proc Natl Acad Sci U S A       Date:  1994-01-18       Impact factor: 11.205

5.  Vesicle targeting to the apical domain regulates bile excretory function in isolated rat hepatocyte couplets.

Authors:  J L Boyer; C J Soroka
Journal:  Gastroenterology       Date:  1995-11       Impact factor: 22.682

Review 6.  Lipid mediators and protein kinase C activation for the intracellular signaling network.

Authors:  S Nakamura; Y Nishizuka
Journal:  J Biochem       Date:  1994-06       Impact factor: 3.387

Review 7.  Ursodeoxycholic acid therapy of chronic cholestatic conditions in adults and children.

Authors:  R Poupon; R E Poupon
Journal:  Pharmacol Ther       Date:  1995-04       Impact factor: 12.310

8.  Tauroursodeoxycholic acid activates protein kinase C in isolated rat hepatocytes.

Authors:  U Beuers; D C Throckmorton; M S Anderson; C M Isales; W Thasler; G A Kullak-Ublick; G Sauter; H G Koebe; G Paumgartner; J L Boyer
Journal:  Gastroenterology       Date:  1996-05       Impact factor: 22.682

9.  Effects of ursodeoxycholic acid on survival in patients with primary biliary cirrhosis.

Authors:  K D Lindor; T M Therneau; R A Jorgensen; M Malinchoc; E R Dickson
Journal:  Gastroenterology       Date:  1996-05       Impact factor: 22.682

10.  Ursodeoxycholic acid inhibits glucagon-induced cAMP formation in hamster hepatocytes: a role for PKC.

Authors:  B Bouscarel; T W Gettys; H Fromm; H Dubner
Journal:  Am J Physiol       Date:  1995-02
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  3 in total

1.  Hepatoprotection with tauroursodeoxycholate and beta muricholate against taurolithocholate induced cholestasis: involvement of signal transduction pathways.

Authors:  P Milkiewicz; M G Roma; E Elias; R Coleman
Journal:  Gut       Date:  2002-07       Impact factor: 23.059

2.  Transcriptional regulation of human mucin MUC4 by bile acids in oesophageal cancer cells is promoter-dependent and involves activation of the phosphatidylinositol 3-kinase signalling pathway.

Authors:  Christophe Mariette; Michaël Perrais; Emmanuelle Leteurtre; Nicolas Jonckheere; Brigitte Hémon; Pascal Pigny; Surinder Batra; Jean-Pierre Aubert; Jean-Pierre Triboulet; Isabelle Van Seuningen
Journal:  Biochem J       Date:  2004-02-01       Impact factor: 3.857

3.  Ischemia-Reperfusion Injury and Ischemic-Type Biliary Lesions following Liver Transplantation.

Authors:  Raffaele Cursio; Jean Gugenheim
Journal:  J Transplant       Date:  2012-02-29
  3 in total

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