Literature DB >> 9625824

Hepatocyte growth factor and Met/HGF receptors in patients with gastric adenocarcinoma.

C W Wu1, A F Li, C W Chi, W W Chung, T Y Liu, W Y Lui, F K P'eng.   

Abstract

Overexpression and amplification of Met/HGF receptor has been detected in gastric cancer tissues and cell lines. In this study hepatocyte growth factor (HGF) and Met/HGF receptors were localized in 32 gastric cancer and adjacent normal gastric tissues by the avidin-biotin-peroxidase complex technique. HGF (87.5%) and Met/HGF receptors (68.8%) were demonstrated in gastric cancer tissues. A high positive rate of HGF (87.0%) and Met/ HGF receptors (82.6%) presented in intestinal type gastric cancer. HGF immunoreactivity in gastric cancer tissues was a significant and powerful prognostic indicator (relative risk 15.9; p=0.01). These data suggest that HGF and Met/HGF receptors are involved in the morphogenesis of intestinal type gastric cancer. HGF may have other mechanism that favor gastric cancer spread and independently affect survival.

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Year:  1998        PMID： 9625824     DOI： 10.3892/or.5.4.817

Source DB:  PubMed          Journal:  Oncol Rep        ISSN： 1021-335X            Impact factor:   3.906


  12 in total

1.  A phase II trial of a selective c-Met inhibitor tivantinib (ARQ 197) monotherapy as a second- or third-line therapy in the patients with metastatic gastric cancer.

Authors:  Yoon-Koo Kang; Kei Muro; Min-Hee Ryu; Hirofumi Yasui; Tomohiro Nishina; Baek-Yeol Ryoo; Yukimasa Kamiya; Shiro Akinaga; Narikazu Boku
Journal:  Invest New Drugs       Date:  2013-12-15       Impact factor: 3.850

2.  Human gastric cancer kinase profile and prognostic significance of MKK4 kinase.

Authors:  C W Wu; A F Li; C W Chi; C L Huang; K H Shen; W Y Liu; W Lin
Journal:  Am J Pathol       Date:  2000-06       Impact factor: 4.307

3.  Exposure-Response and Tumor Growth Inhibition Analyses of the Monovalent Anti-c-MET Antibody Onartuzumab (MetMAb) in the Second- and Third-Line Non-Small Cell Lung Cancer.

Authors:  Kelong Han; Pascal Chanu; Fredrik Jonsson; Helen Winter; René Bruno; Jin Jin; Mark Stroh
Journal:  AAPS J       Date:  2016-12-27       Impact factor: 4.009

Review 4.  MET: a promising anticancer therapeutic target.

Authors:  Solange Peters; Alex A Adjei
Journal:  Nat Rev Clin Oncol       Date:  2012-05-08       Impact factor: 66.675

Review 5.  Second-line treatment of metastatic gastric cancer: Current options and future directions.

Authors:  Dheepak Kanagavel; Mikhail Fedyanin; Alexey Tryakin; Sergei Tjulandin
Journal:  World J Gastroenterol       Date:  2015-11-07       Impact factor: 5.742

6.  Met receptor tyrosine kinase signals through a cortactin-Gab1 scaffold complex, to mediate invadopodia.

Authors:  Charles V Rajadurai; Serhiy Havrylov; Kossay Zaoui; Richard Vaillancourt; Matthew Stuible; Monica Naujokas; Dongmei Zuo; Michel L Tremblay; Morag Park
Journal:  J Cell Sci       Date:  2012-02-24       Impact factor: 5.285

7.  Exposure-response analysis of rilotumumab in gastric cancer: the role of tumour MET expression.

Authors:  M Zhu; R Tang; S Doshi; K S Oliner; S Dubey; Y Jiang; R C Donehower; T Iveson; E Y Loh; Y Zhang
Journal:  Br J Cancer       Date:  2015-01-13       Impact factor: 7.640

Review 8.  C-Met as a prognostic marker in gastric cancer: a systematic review and meta-analysis.

Authors:  Shan Yu; Yiyi Yu; Naiqing Zhao; Jianlan Cui; Wei Li; Tianshu Liu
Journal:  PLoS One       Date:  2013-11-04       Impact factor: 3.240

Review 9.  Molecular classification of gastric cancer: Towards a pathway-driven targeted therapy.

Authors:  Ismael Riquelme; Kathleen Saavedra; Jaime A Espinoza; Helga Weber; Patricia García; Bruno Nervi; Marcelo Garrido; Alejandro H Corvalán; Juan Carlos Roa; Carolina Bizama
Journal:  Oncotarget       Date:  2015-09-22

Review 10.  Challenges and future of biomarker tests in the era of precision oncology: Can we rely on immunohistochemistry (IHC) or fluorescence in situ hybridization (FISH) to select the optimal patients for matched therapy?

Authors:  Young Kwang Chae; Ayush Arya; Lauren Chiec; Hiral Shah; Ari Rosenberg; Sandip Patel; Kirtee Raparia; Jaehyuk Choi; Derek A Wainwright; Victoria Villaflor; Massimo Cristofanilli; Francis Giles
Journal:  Oncotarget       Date:  2017-08-01
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