OBJECTIVE: To study the relationships between apoE phenotypes, dementia, and mortality. SETTING: A population-based study in Helsinki, Finland (the Helsinki Ageing Study). DESIGN: A prospective birth cohort study with 5-year follow-up. PARTICIPANTS: A total of 550 subjects of three birth cohorts of 75 (n = 182), 80 (n = 185), and 85 (n = 183) years of age. MEASUREMENTS: ApoE phenotype was determined from baseline blood samples. The cognitive function of the subjects was tested at baseline and at a 5-year follow-up using the Mini-Mental State Examination (MMSE) and the Clinical Dementia Rating (CDR). Diagnosis and type of dementia were determined by a neurologist. The cohorts were followed for 5 years, and causes of death were determined. Cox proportional hazards model was used for survival analyses. Analyses were performed comparing the apoE e4 allele and others. RESULTS: At baseline, the apoE e4 allele was found in 148 of 550 subjects (27%), in 24% of nondemented persons, in 51% of patients with probable or uncertain Alzheimer's disease (AD), and in 34% patients with vascular dementia. The CDR score was worse among subjects with an e4 allele compared with others at baseline (P < .001) and after a 5-year follow-up (P = .007). The crude mortality rates of subjects with and without an e4 allele were 48% (n = 71) and 37% (n = 148), respectively. After controlling for age and gender, the hazard ratio of an e4 allele was 1.61 (95% CI, 1.21-2.14) for all-cause mortality, deaths caused by dementia 2.20 (95% CI, 1.03-4.72), and presence of AD 3.24 (95% CI, 1.67-6.25). CONCLUSIONS: In a population aged 75 to 85 years, the presence of an apoE e4 allele is associated with impaired cognitive function, clinical dementia, AD, and excess 5-year mortality resulting from dementia and all causes.
OBJECTIVE: To study the relationships between apoE phenotypes, dementia, and mortality. SETTING: A population-based study in Helsinki, Finland (the Helsinki Ageing Study). DESIGN: A prospective birth cohort study with 5-year follow-up. PARTICIPANTS: A total of 550 subjects of three birth cohorts of 75 (n = 182), 80 (n = 185), and 85 (n = 183) years of age. MEASUREMENTS: ApoE phenotype was determined from baseline blood samples. The cognitive function of the subjects was tested at baseline and at a 5-year follow-up using the Mini-Mental State Examination (MMSE) and the Clinical Dementia Rating (CDR). Diagnosis and type of dementia were determined by a neurologist. The cohorts were followed for 5 years, and causes of death were determined. Cox proportional hazards model was used for survival analyses. Analyses were performed comparing the apoE e4 allele and others. RESULTS: At baseline, the apoE e4 allele was found in 148 of 550 subjects (27%), in 24% of nondemented persons, in 51% of patients with probable or uncertain Alzheimer's disease (AD), and in 34% patients with vascular dementia. The CDR score was worse among subjects with an e4 allele compared with others at baseline (P < .001) and after a 5-year follow-up (P = .007). The crude mortality rates of subjects with and without an e4 allele were 48% (n = 71) and 37% (n = 148), respectively. After controlling for age and gender, the hazard ratio of an e4 allele was 1.61 (95% CI, 1.21-2.14) for all-cause mortality, deaths caused by dementia 2.20 (95% CI, 1.03-4.72), and presence of AD 3.24 (95% CI, 1.67-6.25). CONCLUSIONS: In a population aged 75 to 85 years, the presence of an apoE e4 allele is associated with impaired cognitive function, clinical dementia, AD, and excess 5-year mortality resulting from dementia and all causes.
Authors: Maria G Matera; Daniele Sancarlo; Francesco Panza; Carolina Gravina; Grazia D'Onofrio; Vincenza Frisardi; Grazia Longo; Luigi P D'Ambrosio; Filomena Addante; Massimiliano Copetti; Vincenzo Solfrizzi; Davide Seripa; Alberto Pilotto Journal: Age (Dordr) Date: 2010-04-20
Authors: Peter Martin; S Michal Jazwinski; Adam Davey; Robert C Green; Maurice Macdonald; Jennifer A Margrett; Ilene C Siegler; Jonathan Arnold; John L Woodard; Mary Ann Johnson; Sangkyu Kim; Jianliang Dai; Li Li; Mark A Batzer; Leonard W Poon Journal: Aging Ment Health Date: 2013-09-02 Impact factor: 3.658
Authors: May A Beydoun; Hind A Beydoun; Jay S Kaufman; Yang An; Susan M Resnick; Richard O'Brien; Luigi Ferrucci; Alan B Zonderman Journal: J Am Geriatr Soc Date: 2013-03-21 Impact factor: 5.562
Authors: Richard B Lipton; Jamie Hirsch; Mindy J Katz; Cuiling Wang; Amy E Sanders; Joe Verghese; Nir Barzilai; Carol A Derby Journal: J Am Geriatr Soc Date: 2010-05-07 Impact factor: 5.562
Authors: Ajay K Parsaik; Maria I Lapid; Teresa A Rummans; Ruth H Cha; Bradley F Boeve; Vernon S Pankratz; Eric G Tangalos; Ronald C Petersen Journal: J Am Med Dir Assoc Date: 2012-08-03 Impact factor: 4.669