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Literature DB >> 9624505

In vitro activities of the new ketolide antibiotics HMR 3004 and HMR 3647 against Streptococcus pneumoniae in Germany.

Abstract

The comparative in vitro activity of HMR 3004 and HMR 3647, new ketolide antibiotics, was tested by a standard agar dilution technique against 221 pneumococcal strains, including isolates with intermediate levels of resistance to penicillin and erythromycin-resistant isolates. The ketolides were more active than other macrolides and showed excellent activity against erythromycin-resistant strains. All the strains were inhibited by < or = 2 micrograms of HMR 3004/ml or by < or = 0.5 microgram of HMR 3647/ml.

Entities: Chemical Disease Species

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Year: 1998 PMID： 9624505 PMCID： PMC105633

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

17 in total

1. Penicillin-resistant pneumococcus in community-acquired bacteremic pneumonia in Germany.

Authors: R R Reinert; A Kaufhold; H Kierdorf
Journal: Infection Date: 1992 Jul-Aug Impact factor: 3.553

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Authors: P Geslin; A Buu-Hoi; A Frémaux; J F Acar
Journal: Clin Infect Dis Date: 1992-07 Impact factor: 9.079

3. Serotype distribution and antibiotic susceptibility of Streptococcus pneumoniae isolates causing systemic infections among children in Germany, 1992 to 1996.

Authors: R R Reinert; A Kaufhold; J J Schlaeger; V Mechery; R Lütticken
Journal: Pediatr Infect Dis J Date: 1997-02 Impact factor: 2.129

4. Antimicrobial resistance of Streptococcus pneumoniae recovered from outpatients in the United States during the winter months of 1994 to 1995: results of a 30-center national surveillance study.

Authors: G V Doern; A Brueggemann; H P Holley; A M Rauch
Journal: Antimicrob Agents Chemother Date: 1996-05 Impact factor: 5.191

5. Serotypes and antimicrobial susceptibility of Streptococcus pneumoniae in West Germany.

Authors: D Milatović; K Machka; W Heck; I Braveny
Journal: Infection Date: 1981 Impact factor: 3.553

6. Antimicrobial resistance and type distribution of Streptococcus pneumoniae isolates causing systemic infections in Germany, 1992-1994.

Authors: R R Reinert; A Queck; A Kaufhold; M Kresken; R Lütticken
Journal: Clin Infect Dis Date: 1995-12 Impact factor: 9.079

Review 7. Antimicrobial resistance in Streptococcus pneumoniae: an overview.

Authors: P C Appelbaum
Journal: Clin Infect Dis Date: 1992-07 Impact factor: 9.079

8. Pneumococcal antimicrobial resistance: the problem in Hungary.

Authors: A Marton
Journal: Clin Infect Dis Date: 1992-07 Impact factor: 9.079

9. In vitro evaluation of a novel ketolide antimicrobial agent, RU-64004.

Authors: C Jamjian; D J Biedenbach; R N Jones
Journal: Antimicrob Agents Chemother Date: 1997-02 Impact factor: 5.191

10. [Current data on the antibiotic sensitivity of Streptococcus pneumoniae (Pneumococcus). The significance of penicillin resistant isolates].

Authors: R R Reinert; R Lütticken; A Kaufhold
Journal: Med Klin (Munich) Date: 1993-06-15

18 in total

1. Differentiation of resistance phenotypes among erythromycin-resistant Pneumococci.

Authors: M P Montanari; M Mingoia; E Giovanetti; P E Varaldo
Journal: J Clin Microbiol Date: 2001-04 Impact factor: 5.948

2. In vitro activity of ABT 773, a new ketolide antibiotic, against Chlamydia pneumoniae.

Authors: S Strigl; P M Roblin; T Reznik; M R Hammerschlag
Journal: Antimicrob Agents Chemother Date: 2000-04 Impact factor: 5.191

3. Postantibiotic suppression of growth of erythromycin A-susceptible and -resistant gram-positive bacteria by the ketolides telithromycin (HMR 3647) and HMR 3004.

Authors: W J Munckhof; G Borlace; J D Turnidge
Journal: Antimicrob Agents Chemother Date: 2000-06 Impact factor: 5.191

4. In vitro activities of the ketolides telithromycin (HMR 3647) and HMR 3004 compared to those of clarithromycin against slowly growing mycobacteria at pHs 6.8 and 7.4.

Authors: N Rastogi; K S Goh; M Berchel; A Bryskier
Journal: Antimicrob Agents Chemother Date: 2000-10 Impact factor: 5.191

5. In vitro development of resistance to telithromycin (HMR 3647), four macrolides, clindamycin, and pristinamycin in Streptococcus pneumoniae.

Authors: T A Davies; B E Dewasse; M R Jacobs; P C Appelbaum
Journal: Antimicrob Agents Chemother Date: 2000-02 Impact factor: 5.191

Review 6. Review of macrolides and ketolides: focus on respiratory tract infections.

Authors: G G Zhanel; M Dueck; D J Hoban; L M Vercaigne; J M Embil; A S Gin; J A Karlowsky
Journal: Drugs Date: 2001 Impact factor: 9.546

7. In vitro activities of the new ketolide HMR 3647 (telithromycin) in comparison with those of eight other antibiotics against viridans group Streptococci isolated from blood of neutropenic patients with cancer.

Authors: F Alcaide; M A Benítez; J Carratalà; F Gudiol; J Liñares; R Martín
Journal: Antimicrob Agents Chemother Date: 2001-02 Impact factor: 5.191

8. In vitro pharmacodynamics of the new ketolides HMR 3004 and HMR 3647 (Telithromycin) against Chlamydia pneumoniae.

Authors: I Gustafsson; E Hjelm; O Cars
Journal: Antimicrob Agents Chemother Date: 2000-07 Impact factor: 5.191

9. Bronchopulmonary disposition of the ketolide telithromycin (HMR 3647).

Authors: C Muller-Serieys; P Soler; C Cantalloube; F Lemaitre; H P Gia; F Brunner; A Andremont
Journal: Antimicrob Agents Chemother Date: 2001-11 Impact factor: 5.191

Review 10. The ketolides: a critical review.

Authors: George G Zhanel; Michael Walters; Ayman Noreddin; Lavern M Vercaigne; Aleksandra Wierzbowski; John M Embil; Alfred S Gin; Stephen Douthwaite; Daryl J Hoban
Journal: Drugs Date: 2002 Impact factor: 9.546