| Literature DB >> 962422 |
E I Takesue, J W Perrine, J H Trapold.
Abstract
Proquazone, 1-isopropyl-4-phenyl-7-methyl-2(1H)-quinazolinone is an orally effective anti-inflammatory analgesic and antipyretic compound in animal models. The compound is less ulcerogenic than indomethacin in the rat and appears to potentiate the anti-inflammatory and thymus involution effects of hydrocortisone in this species. That a nonacidic nonsteroidal compound would display a spectrum of anti-inflammatory activity similar to that previously found only with acidic compounds will be the subject of further investigations.Entities:
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Year: 1976 PMID： 962422
Source DB: PubMed Journal: Arch Int Pharmacodyn Ther ISSN： 0003-9780