Literature DB >> 9622602

Regulation of phospholipase C-delta by GTP-binding proteins-rhoA as an inhibitory modulator.

E A Hodson1, C C Ashley, A D Hughes, J S Lymn.   

Abstract

The regulation of Phospholipase C (PLC)delta activity remains obscure. These studies show that PLCdelta1 activity is significantly enhanced by both guanosine thiotriphosphate (GTPgammaS) and Clostridium botulinum exoenzyme C3 (C3) but not by aluminium fluoride. C3 ADP ribosylated a 21-kDa protein in the PLCdelta1 preparation and Western blotting identified rhoA in these samples. RhoA acts as an inhibitory modulator of PLCdelta activity. Copyright 1998 Elsevier Science B.V. All rights reserved.

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Year:  1998        PMID： 9622602     DOI： 10.1016/s0167-4889(98)00028-7

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  9 in total

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4.  Critical roles of Gi/o proteins and phospholipase C-δ1 in the activation of receptor-operated TRPC4 channels.

Authors:  Dhananjay P Thakur; Jin-bin Tian; Jaepyo Jeon; Jian Xiong; Yu Huang; Veit Flockerzi; Michael X Zhu
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Authors:  Yoshikazu Nakamura; Yoshio Hamada; Takashi Fujiwara; Hiroko Enomoto; Takeshi Hiroe; Satoshi Tanaka; Masato Nose; Masamichi Nakahara; Nobuaki Yoshida; Tadaomi Takenawa; Kiyoko Fukami
Journal:  Mol Cell Biol       Date:  2005-12       Impact factor: 4.272

6.  Interactions of G(h)/transglutaminase with phospholipase Cdelta1 and with GTP.

Authors:  S N Murthy; J W Lomasney; E C Mak; L Lorand
Journal:  Proc Natl Acad Sci U S A       Date:  1999-10-12       Impact factor: 11.205

7.  Leukotriene D4 induces association of active RhoA with phospholipase C-gamma1 in intestinal epithelial cells.

Authors:  Charles Kumar Thodeti; Ramin Massoumi; Lene Bindslev; Anita Sjölander
Journal:  Biochem J       Date:  2002-07-01       Impact factor: 3.857

8.  Global changes in the rat heart proteome induced by prolonged morphine treatment and withdrawal.

Authors:  Zdenka Drastichova; Jitka Skrabalova; Petr Jedelsky; Jan Neckar; Frantisek Kolar; Jiri Novotny
Journal:  PLoS One       Date:  2012-10-09       Impact factor: 3.240

9.  Intracellular acidification facilitates receptor-operated TRPC4 activation through PLCδ1 in a Ca2+ -dependent manner.

Authors:  Dhananjay P Thakur; Qiaochu Wang; Jaepyo Jeon; Jin-Bin Tian; Michael X Zhu
Journal:  J Physiol       Date:  2020-05-22       Impact factor: 5.182
  9 in total

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