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Literature DB >> 96218

Therapeutic trials in muscular dystrophy. 1. Gold in murine dystrophy.

Abstract

A trial of sodium aurothiomalate as an antiproteinase drug in the treatment of murine muscular dystrophy is reported. A blind controlled comparison of high (25 microgram/10 g body weight) and low dose gold (5 microgram/10 g body weight) with saline-injected control animals was made, all injections being given three times weekly. The body weights and functional ability of the mice were assessed at weekly intervals. No significant difference between the groups was observed. A trial of very high dose chrysotherapy (500 microgram of gold/10 g body weight) also showed no therapeutic benefit.

Entities: Chemical Disease Species

Mesh：

Substances：
Gold Sodium Thiomalate

Year: 1978 PMID： 96218 PMCID： PMC493045 DOI： 10.1136/jnnp.41.5.404

Source DB: PubMed Journal: J Neurol Neurosurg Psychiatry ISSN： 0022-3050 Impact factor: 10.154

20 in total

1. Effects of gold salts and prednisolone on inflammatory cells. II. Suppression of inflammation and phagocytosis in the rat.

Authors: B Vernon-Roberts; J D Jessop; J Doré
Journal: Ann Rheum Dis Date: 1973-07 Impact factor: 19.103

2. Effects of gold salts and prednisolone on inflammatory cells. I. Phagocytic activity of macrophages and polymorphs in inflammatory exudates studied by a "skin-window" technique in rheumatoid and control patients.

Authors: J D Jessop; B Vernon-Roberts; J Harris
Journal: Ann Rheum Dis Date: 1973-07 Impact factor: 19.103

Therapeutic trials in muscular dystrophy. 1. Gold in murine dystrophy.

1. Effects of gold salts and prednisolone on inflammatory cells. II. Suppression of inflammation and phagocytosis in the rat.

2. Effects of gold salts and prednisolone on inflammatory cells. I. Phagocytic activity of macrophages and polymorphs in inflammatory exudates studied by a "skin-window" technique in rheumatoid and control patients.

3. Acid, neutral and alkaline cathepsins in normal and diseased human muscle.

4. Tissue gold concentration in a rheumatoid arthritic receiving chrysotherapy.

5. Gold metabolism in patients with rheumatoid arthritis treated with gold compounds--reinvestigated.

6. Inhibition of human granulocyte elastase by gold sodium thiomalate.

7. Transport of gold in the body.

8. Gold kinetics following aurothiomalate therapy: use of a whole-body radiation counter.

9. The effect of gold salt on lysosomal enzymes of the peritoneal macrophage.

10. Therapeutic trials in muscular dystrophy. III. Studies of microbial proteinase inhibitors in murine dystrophy.

1. 3-Methylhistidine excretion as an index of myofibrillar protein catabolism in neuromuscular disease.