Literature DB >> 9620974

The MTCY428.08 gene of Mycobacterium tuberculosis codes for NAD+ synthetase.

R Cantoni1, M Branzoni, M Labò, M Rizzi, G Riccardi.   

Abstract

The product of the MTCY428.08 gene of Mycobacterium tuberculosis shows sequence homology with several NAD+ synthetases. The MTCY428.08 gene was cloned into the expression vectors pGEX-4T-1 and pET-15b. Expression in Escherichia coli led to overproduction of glutathione S-transferase fused and His6-tagged gene products, which were enzymatically assayed for NAD synthetase activity. Our results demonstrate that the MTCY428.08 gene of M. tuberculosis is the structural gene for NAD+ synthetase.

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Year:  1998        PMID： 9620974      PMCID： PMC107825     

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  17 in total

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Authors:  Isabel Veiga-Malta; Margarida Duarte; Márcia Dinis; Pedro Madureira; Paula Ferreira; Arnaldo Videira
Journal:  J Bacteriol       Date:  2004-01       Impact factor: 3.490

2.  The ATPase activity of the G2alt gene encoding an aluminium tolerance protein from Anoxybacillus gonensis G2.

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3.  Nicotinamide mononucleotide synthetase is the key enzyme for an alternative route of NAD biosynthesis in Francisella tularensis.

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Journal:  Proc Natl Acad Sci U S A       Date:  2009-02-09       Impact factor: 11.205

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