Literature DB >> 9619266

Enzymatic activation of prodrugs by prostate-specific antigen: targeted therapy for metastatic prostate cancer.

S R Denmeade1, J T Isaacs.   

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Year:  1998        PMID: 9619266

Source DB:  PubMed          Journal:  Cancer J Sci Am        ISSN: 1081-4442


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  7 in total

Review 1.  A history of prostate cancer treatment.

Authors:  Samuel R Denmeade; John T Isaacs
Journal:  Nat Rev Cancer       Date:  2002-05       Impact factor: 60.716

2.  Engineering a prostate-specific membrane antigen-activated tumor endothelial cell prodrug for cancer therapy.

Authors:  Samuel R Denmeade; Annastasiah M Mhaka; D Marc Rosen; W Nathaniel Brennen; Susan Dalrymple; Ingrid Dach; Claus Olesen; Bora Gurel; Angelo M Demarzo; George Wilding; Michael A Carducci; Craig A Dionne; Jesper V Møller; Poul Nissen; S Brøgger Christensen; John T Isaacs
Journal:  Sci Transl Med       Date:  2012-06-27       Impact factor: 17.956

3.  Optimization of an albumin-binding prodrug of Doxorubicin that is cleaved by prostate-specific antigen.

Authors:  Bakheet Elsadek; Ralph Graeser; André Warnecke; Clemens Unger; Tahia Saleem; Nagla El-Melegy; Hafez Madkor; Felix Kratz
Journal:  ACS Med Chem Lett       Date:  2010-05-26       Impact factor: 4.345

4.  A prostate-specific antigen-activated channel-forming toxin as therapy for prostatic disease.

Authors:  Simon A Williams; Rosemina F Merchant; Elizabeth Garrett-Mayer; John T Isaacs; J Thomas Buckley; Samuel R Denmeade
Journal:  J Natl Cancer Inst       Date:  2007-03-07       Impact factor: 13.506

5.  Screening for new peptide substrates for the development of albumin binding anticancer pro-drugs that are cleaved by prostate-specific antigen (PSA) to improve the anti tumor efficacy.

Authors:  Bakheet E M Elsadek; Mohammed H Hassan
Journal:  Biochem Biophys Rep       Date:  2021-03-02

6.  The dipeptide monoester prodrugs of floxuridine and gemcitabine-feasibility of orally administrable nucleoside analogs.

Authors:  Yasuhiro Tsume; Blanca Borras Bermejo; Gordon L Amidon
Journal:  Pharmaceuticals (Basel)       Date:  2014-01-27

7.  Mipsagargin, a novel thapsigargin-based PSMA-activated prodrug: results of a first-in-man phase I clinical trial in patients with refractory, advanced or metastatic solid tumours.

Authors:  D Mahalingam; G Wilding; S Denmeade; J Sarantopoulas; D Cosgrove; J Cetnar; N Azad; J Bruce; M Kurman; V E Allgood; M Carducci
Journal:  Br J Cancer       Date:  2016-04-26       Impact factor: 7.640

  7 in total

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