OBJECTIVE: Previous studies, mostly involving neuroleptic-treated patients, have suggested enlarged basal ganglia size in schizophrenia. The authors sought to examine basal ganglia volume in neuroleptic-naive psychotic patients. METHOD: Magnetic resonance imaging volumetric studies were conducted in newly diagnosed neuroleptic-naive schizophrenic and non-schizophrenic psychotic patients and in matched healthy comparison subjects. RESULTS: Both patient groups had bilaterally reduced caudate, but not putamen, volumes, compared to the healthy subjects, after adjustment for intracranial volume. CONCLUSIONS: Decreases in caudate volume in newly diagnosed psychotic patients may be related to the primary pathophysiology of these disorders; prior observations of increased caudate volume may reflect effects of neuroleptic treatment.
OBJECTIVE: Previous studies, mostly involving neuroleptic-treated patients, have suggested enlarged basal ganglia size in schizophrenia. The authors sought to examine basal ganglia volume in neuroleptic-naive psychoticpatients. METHOD: Magnetic resonance imaging volumetric studies were conducted in newly diagnosed neuroleptic-naive schizophrenic and non-schizophrenic psychoticpatients and in matched healthy comparison subjects. RESULTS: Both patient groups had bilaterally reduced caudate, but not putamen, volumes, compared to the healthy subjects, after adjustment for intracranial volume. CONCLUSIONS: Decreases in caudate volume in newly diagnosed psychoticpatients may be related to the primary pathophysiology of these disorders; prior observations of increased caudate volume may reflect effects of neuroleptic treatment.
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Authors: James J Levitt; Robert W McCarley; Chandlee C Dickey; Martina M Voglmaier; Margaret A Niznikiewicz; Larry J Seidman; Yoshio Hirayasu; Aleksandra A Ciszewski; Ron Kikinis; Ferenc A Jolesz; Martha E Shenton Journal: Am J Psychiatry Date: 2002-07 Impact factor: 18.112
Authors: Vicente Molina; Gemma Galindo; Benjamín Cortés; Alba G Seco de Herrera; Ana Ledo; Javier Sanz; Carlos Montes; Juan A Hernández-Tamames Journal: Eur Arch Psychiatry Clin Neurosci Date: 2010-12-28 Impact factor: 5.270
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Authors: Haissam Haidar; Sylvain Bouix; James Levitt; Robert W McCarley; Martha E Shenton; Janet S Soul Journal: Conf Proc IEEE Eng Med Biol Soc Date: 2004
Authors: Haissam Haidar; Sylvain Bouix; James J Levitt; Robert W McCarley; Martha E Shenton; Janet S Soul Journal: IEEE Trans Med Imaging Date: 2006-10 Impact factor: 10.048
Authors: Jee In Kang; Hae-Jeong Park; Se Joo Kim; Kyung Ran Kim; Su Young Lee; Eun Lee; Suk Kyoon An; Jun Soo Kwon; Jong Doo Lee Journal: Schizophr Bull Date: 2013-04-15 Impact factor: 9.306
Authors: Martina Ballmaier; Florian Schlagenhauf; Arthur W Toga; Jürgen Gallinat; Michael Koslowski; Michele Zoli; Cornelius Hojatkashani; Katherine L Narr; Andreas Heinz Journal: Schizophr Res Date: 2008-09-24 Impact factor: 4.939