OBJECTIVE: The authors investigated whether striatal dopamine D2 receptor binding characteristics in vivo are similar in men and women and whether there are sex-related differences in the decline in D2 receptor density due to aging. METHOD: Striatal D2 receptor density (Bmax), affinity (Kd), and binding potential (Bmax/Kd) were measured with positron emission tomography and [11C]raclopride in 54 healthy subjects (33 men and 21 women). RESULTS: Women had generally lower D2 receptor affinity than men, and this difference was statistically significant in the left striatum. Bmax and Bmax/Kd tended to decline with age twice as fast in men as in women, but the difference did not reach statistical significance. CONCLUSIONS: These results confirm the age-related reduction of D2 receptor density and binding potential in both sexes in vivo. The lower D2 receptor affinity suggests an increased endogenous striatal dopamine concentration in women. This may have implications for the differential vulnerability of men and women to psychiatric disorders like schizophrenia and alcohol and substance dependence.
OBJECTIVE: The authors investigated whether striatal dopamine D2 receptor binding characteristics in vivo are similar in men and women and whether there are sex-related differences in the decline in D2 receptor density due to aging. METHOD: Striatal D2 receptor density (Bmax), affinity (Kd), and binding potential (Bmax/Kd) were measured with positron emission tomography and [11C]raclopride in 54 healthy subjects (33 men and 21 women). RESULTS:Women had generally lower D2 receptor affinity than men, and this difference was statistically significant in the left striatum. Bmax and Bmax/Kd tended to decline with age twice as fast in men as in women, but the difference did not reach statistical significance. CONCLUSIONS: These results confirm the age-related reduction of D2 receptor density and binding potential in both sexes in vivo. The lower D2 receptor affinity suggests an increased endogenous striatal dopamine concentration in women. This may have implications for the differential vulnerability of men and women to psychiatric disorders like schizophrenia and alcohol and substance dependence.
Authors: A Meyer; D N Klein; D C Torpey; A J Kujawa; E P Hayden; H I Sheikh; S M Singh; G Hajcak Journal: Genes Brain Behav Date: 2012-06-28 Impact factor: 3.449
Authors: Linh C Dang; Jaime J Castrellon; Scott F Perkins; Nam T Le; Ronald L Cowan; David H Zald; Gregory R Samanez-Larkin Journal: Neuroimage Date: 2017-01-10 Impact factor: 6.556
Authors: Eli J Cornblath; Evelyn Tang; Graham L Baum; Tyler M Moore; Azeez Adebimpe; David R Roalf; Ruben C Gur; Raquel E Gur; Fabio Pasqualetti; Theodore D Satterthwaite; Danielle S Bassett Journal: Neuroimage Date: 2018-12-01 Impact factor: 6.556
Authors: Kendra L Seaman; Christopher T Smith; Eric J Juarez; Linh C Dang; Jaime J Castrellon; Leah L Burgess; M Danica San Juan; Paul M Kundzicz; Ronald L Cowan; David H Zald; Gregory R Samanez-Larkin Journal: Hum Brain Mapp Date: 2019-04-01 Impact factor: 5.038
Authors: Arthur L Brody; Mark A Mandelkern; Richard E Olmstead; Zoe Allen-Martinez; David Scheibal; Anna L Abrams; Matthew R Costello; Judah Farahi; Sanjaya Saxena; John Monterosso; Edythe D London Journal: Neuropsychopharmacology Date: 2008-06-18 Impact factor: 7.853