Photosensitivity reaction to fluoxetine and alprazolam.

We report the case of a male individual who developed a severe photosensitive reaction after sun exposure during therapy with fluoxetin 20 mg bid plus alprazolam 0.25 mg bid due to depressive disturbances. The patients, of North-African origin, was not taking other prescription medications nor over the counter products; in the past he had never shown any reaction to sunlight nor had ever used sun protective agents because of its phenotypical skin mark. Three months later, after a second photosensitive reaction, the pharmacological therapy was finally discontinued.